SML1170

SR2211

≥98% (HPLC)

• Synonyme(s) : 1,1,1,3,3,3-Hexafluoro-2-(2-fluoro-4-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1-biphenyl]-4-yl)propan-2-ol, ;2-Fluoro-4′-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1′-biphenyl]-4-methanol, ML310
• Formule empirique (notation de Hill): C₂₆H₂₄F₇N₃O
• Numéro CAS: 1359164-11-6
• Poids moléculaire : 527.48
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Température de stockage: −20°C
• InChI: 1S/C26H24F7N3O/c27-23-15-21(24(37,25(28,29)30)26(31,32)33)5-6-22(23)20-3-1-18(2-4-20)16-35-11-13-36(14-12-35)17-19-7-9-34-10-8-19/h1-10,15,37H,11-14,16-17H2
• Clé InChI: KVHKWAZUPPBMLL-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

SR2211 (ML310) is a potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (RORγ). RORγ is essential for interleukin 17 expression and differentiation of TH17 cells, important in autoimmune diseases including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and lupus. SR2211 (ML310) treatment of EL-4 murine T lymphocyte cells resulted in suppression of gene expression and production of IL-17 with an IC₅₀ ~320 nM with no effect on the transcriptional activity of RORγ. In a mouse model of rheumatoid arthritis, SR2211 significantly reduced joint inflammation, suppressing inflammatory T cell function, expression and production of inflammatory cytokines, and macrophage activation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable