SML1165

Talnetant

≥98% (HPLC)

• Synonyme(s) : (S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide, SB-223412
• Formule empirique (notation de Hill): C₂₅H₂₂N₂O₂
• Numéro CAS: 174636-32-9
• Poids moléculaire : 382.45
• Numéro MDL: MFCD00944075
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825695
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D -25 to -31°, c = 0.5 in methanol
• Couleur: white to beige
• Solubilité: DMSO: 25 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(C(C(N[C@H](C1=CC=CC=C1)CC)=O)=C(C=CC=C2)C2=N3)=C3C4=CC=CC=C4
• InChI: 1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1
• Clé InChI: BIAVGWDGIJKWRM-FQEVSTJZSA-N
• Informations sur le gène: human ... TACR3(6870)

Description

Actions biochimiques/physiologiques

Talnetant (SB-223,412) is a highly selective antagonist of neurokinin 3 receptor with a Ki (NK3) = 1 nM >10000 (NK1) >140 (NK2). Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract. Talnetant was in clinical trials for both irritable bowel syndrome and schizophrenia.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable