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SML1072

Sigma-Aldrich

GSK-LSD1

≥98% (HPLC)

Synonyme(s) :

GSK-LSD1 (trans-racemic) dihydrochloride, rel- N-[(1R,2S)-2-Phenylcyclopropyl]-4-Piperidinamine hydrochloride (1:2)

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About This Item

Formule empirique (notation de Hill):
C14H20N2 · 2HCl
Numéro CAS:
1431368-48-7
Poids moléculaire :
289.24
Code UNSPSC :
51111800
ID de substance PubChem :
329825454
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

H2O: 20 mg/mL, clear

Température de stockage

2-8°C

Chaîne SMILES 

C1(N[C@@H]2C[C@H]2C3=CC=CC=C3)CCNCC1

InChI

1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1

Clé InChI

BASFYRLYJAZPPL-UONOGXRCSA-N

Catégories apparentées

Application

GSK-LSD1 has been used as a lysine specific demethylase 1 (LSD1) inhibitor in mice to study sepsis-induced mortality. It has also been used as an inhibitor to study if the effect of phenelzine activation of human immunodeficiency virus (HIV) latency is caused due to LSD1.

Actions biochimiques/physiologiques

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. For full characterization details, please visit the GSK-LSD1 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Caractéristiques et avantages

GSK-LSD1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

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SML0662

UNC1215, ≥98% (HPLC)

SML0701

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SML0709

GSK-J1, ≥98% (HPLC)

SML0768

GSK2801, ≥98% (HPLC)

SML0766

GSK343, ≥98% (HPLC)

SML0778

UNC1999, ≥98% (HPLC)

SML0974

(+/-)-JQ1, ≥98% (HPLC)

SML0992

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SML0939

PFI-3, ≥98% (HPLC)

SML1037

UNC0642, ≥98% (HPLC)

SML1107

SGC0946, ≥98% (HPLC)

SML1133

SGC-CBP30, ≥98% (HPLC)

SML1134

I-CBP112, ≥98% (HPLC)

SML1184

OF-1, ≥98% (HPLC)

SML1209

OICR-9429, ≥98% (HPLC)

SML1242

SGC707, ≥98% (HPLC)

SML1279

LLY-507, ≥97% (HPLC)

SML1276

BAZ2-ICR, ≥98% (HPLC)

PZ0307

PFI-4, ≥98% (HPLC)

SML1408

(R)-PFI-2, ≥97% (HPLC)

SML1410

A-366, ≥98% (HPLC)

SML1486

NI-57, ≥98% (HPLC)

PZ0312

(S)-PFI-2

SML1534

I-BRD9, ≥98% (HPLC)

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Ribonucléase A from bovine pancreas for molecular biology, ≥70 Kunitz units/mg protein, lyophilized

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Millipore

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PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response
Kim D, et al.
Molecular Cell, 69(3), 398-411 (2018)
Agatheeswaran Subramaniam et al.
Blood, 136(19), 2151-2161 (2020-06-26)
Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human cord blood-derived
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency
Llewellyn GN, et al.
Journal of Neurovirology, 1-12 (2017)
Carl M Gay et al.
Cancer cell, 39(3), 346-360 (2021-01-23)
Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a single entity with predictably poor results. Using tumor expression data and non-negative matrix factorization, we identify four SCLC subtypes defined largely by differential expression of transcription
Kimberly N Smitheman et al.
Haematologica, 104(6), 1156-1167 (2018-12-06)
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1, has previously been described. Inhibition
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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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