SML0085

A-967079

≥98% (HPLC)

• Synonyme(s) : (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime
• Formule empirique (notation de Hill): C₁₂H₁₄FNO
• Numéro CAS: 1170613-55-4
• Poids moléculaire : 207.24
• Numéro MDL: MFCD20488058
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825146
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO: ≥12 mg/mL
• Auteur: Abbott
• Température de stockage: 2-8°C
• Chaîne SMILES: CCC(=N/O)\C(C)=C\c1ccc(F)cc1
• InChI: 1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
• Clé InChI: HKROEBDHHKMNBZ-CHBKHGQFSA-N

Description

Description générale

A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.

Application

A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.

Actions biochimiques/physiologiques

A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC₅₀′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.

Caractéristiques et avantages

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable