SML0066

NGB 2904 hydrochloride

≥98% (HPLC)

• Synonyme(s) : N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride
• Formule empirique (notation de Hill): C₂₈H₂₉Cl₂N₃O·HCl
• Numéro CAS: 189061-11-8
• Poids moléculaire : 530.92
• Numéro MDL: MFCD09971107
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825130
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to tan
• Solubilité: DMSO: ≥25 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
• InChI: 1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H
• Clé InChI: PFIWYJNBKGCVFM-UHFFFAOYSA-N

Description

Application

NGB 2904 hydrochloride may be used in cell signaling studies.

Actions biochimiques/physiologiques

Inhibition of dopamine D₃ receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.

NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

Caractéristiques et avantages

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable