SAB5700387

Anti-Phospho-p38 MAPK-T180/Y182 antibody produced in rabbit

• Synonyme(s) : CSBP, CSBP1, CSBP2, CSPB1, EXIP, MAPK14, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38 MAPK, p38ALPHA
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.43

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: 29; 34; 35; 41
• Espèces réactives: mouse, human, rat
• Concentration: 5.56 mg/ml
• Technique(s): immunofluorescence: 1:50-1:200; western blot: 1:500-1:2000
• Numéro d'accès UniProt: Q16539
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pThr180/pTyr182)
• Informations sur le gène: human ... MAPK14(1432)

Description

Description générale

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Immunogène

A synthetic phosphorylated peptide around T180 & Y182 of human p38 MAPK (NP_620581.1).

Forme physique

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Stockage et stabilité

Store at -20℃. Avoid freeze / thaw cycles.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable