SAB5200020

Monoclonal Anti-MDC1 antibody produced in mouse

clone P2B11, 1 mg/mL, purified immunoglobulin

• Synonyme(s) : Anti-MDC1, P2B11, Anti-Nuclear factor with BRCT domains1, Anti-mediator of DNA damage checkpoint 1
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: P2B11, monoclonal
• Forme: buffered aqueous glycerol solution
• Poids mol.: antigen predicted mol wt 184 kDa
• Espèces réactives: human, mouse, bovine, chimpanzee
• Concentration: 1 mg/mL
• Technique(s): indirect immunofluorescence: suitable; western blot: suitable
• Isotype: IgG1
• Numéro d'accès NCBI: NP_001010833.2
• Numéro d'accès UniProt: Q14676
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: mouse ... MDC1(240087)

Description

Description générale

Mediator of DNA damage checkpoint 1 (MDC1) is a nuclear protein that in humans is encoded by the MDC1 gene mapped to chromosome 6p21.33. The encoded protein is widely expressed in various types of tissues and organs. MDC1 is characterized with two BRCA1 C terminus (BRCT) domain, an N-terminal phosphoamino-acid-binding motif called a forkhead-associated (FHA) domain and large central proline/serine/threonine-rich repeat (PST) domain.

Spécificité

Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus.

Immunogène

GST-tagged recombinant protein corresponding to mouse MDC1 ar and around the N-termius

Actions biochimiques/physiologiques

Mediator of DNA damage checkpoint 1 (MDC1) plays a vital role in stimulation of the intra–S phase and G2-M phase checkpoints of the cell cycle in response to DNA damage. Polymorphism of the gene has been associated with the development of both the serum LDL-cholesterol concentration and hyper–LDL-cholesterolemia. Mammalian MDC1/ nuclear factor with BRCT domain 1 (NFBD1) interacts with phospho-H2AX (γH2AX) and plays a key role in DNA damage response by facilitating normal radioresistance and efficient accumulation of DNA-damage-response proteins on damaged chromatin.

Caractéristiques et avantages

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Forme physique

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable