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Key Documents

SAB4504476

Sigma-Aldrich

Anti-phospho-mTOR (pSer2448) antibody produced in rabbit

affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 288 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P42345

Numéro d'accès UniProt

P42345

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer2448)

Informations sur le gène

human ... MTOR(2475)

Catégories apparentées

Description générale

The mechanistic/mammalian target of rapamycin (mTOR) is a serine/threonine kinase. It is a member of the phosphatidylinositide 3-kinases (PI 3-kinases or PI3Ks) family. It is mapped to human chromosome 1p36.22.

Immunogène

The antiserum was produced against synthesized peptide derived from human mTOR around the phosphorylation site of Ser2448.

Immunogen Range: 2415-2464

Application

Anti-phospho-mTOR (pSer2448) antibody has been used in western blotting.

Actions biochimiques/physiologiques

The mechanistic/mammalian target of rapamycin (mTOR) controls protein translation, cell growth, survival, invasion and metabolism. It acts as an intracellular signalling regulator, which links the extracellular events to the intracellular process. mTOR also acts on the protein synthesis machinery.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Jie Yuan et al.
International journal of molecular medicine, 41(4), 2086-2098 (2018-01-19)
Presbycusis is the most common sensory impairment associated with aging; however, the underlying molecular mechanism remains unclear. Autophagy has been demonstrated to serve a key role in diverse diseases; however, no studies have examined its function in central presbycusis. The
Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition
Marques-Ramos A, et al.
RNA, rna-063040 (2017)
Yulin Zhao et al.
Aging, 13(18), 22459-22473 (2021-09-24)
Emerging studies have revealed that non-coding RNAs contribute to regulating intervertebral disc degeneration (IVDD). Here, we intended to probe into the function of miR-19b-3p in IVDD evolvement. The miR-19b-3p level in the intervertebral disc (IVD) tissues of IVDD patients and
Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway
Yuan J, et al.
International Journal of Molecular Medicine, 41(4), 2086-2098 (2018)
Impaired Cellular Energy Metabolism Contributes to Duck-Enteritis-Virus-Induced Autophagy via the AMPK-TSC2-MTOR Signaling Pathway
Yin H, et al.
Frontiers in Cellular and Infection Microbiology, 7(8), 423-423 (2017)
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