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Key Documents

SAB4501719

Sigma-Aldrich

Anti-LAMA4 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

LAMA4, Laminin subunit α-4

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 202 kDa

Espèces réactives

mouse, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q16363

Numéro d'accès UniProt

Q16363

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... LAMA4(3910)

Description générale

Anti-LAMA4 Antibody detects endogenous levels of total LAMA4 protein.
Laminin-A4 (LAMA4) is a protein that is expressed at high levels in vivo in clusters of hypertrophic chondrocytes. It is located on human chromosome 6q21.

Immunogène

The antiserum was produced against synthesized peptide derived from human LAMA4.

Immunogen Range: 481-530

Application

Anti-LAMA4 antibody has been used in western blotting, immunohistochemistry and immunocytochemistry.

Actions biochimiques/physiologiques

Laminin-A4 (LAMA4) decreases the amount of cellular protrusions in cultured human chondrocytes. It participates in migration, proliferation and survival of several cells. LAMA4 induces invasion, migration and angiogenesis of trophoblast cell.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Effect of Laminin?A4 inhibition on cluster formation of human osteoarthritic chondrocytes.
Moazedi?Fuerst FC, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 34(3), 419-426 (2016)
N Shan et al.
Placenta, 36(8), 809-820 (2015-06-11)
The laminin α4 subunit (LAMA4) has been shown to promote migration, proliferation, and survival of various cell types. This study investigated LAMA4's role in trophoblast cells during placental development. LAMA4 expression was immunohistochemically assessed in the first trimester and term
Laminin α4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas.
Shan N, et al,
Placenta, 36(8), 809?820-809?820 (2015)
The laminin family.
Aumailley M.
Cell adhesion & migration, 7(1), 48-55 (2013)
Anna Goddi et al.
Endocrinology, 163(11) (2022-09-21)
Laminin-α4 (LAMA4) is an extracellular matrix protein implicated in the regulation of adipocyte differentiation and function. Prior research describes a role for LAMA4 in modulating adipocyte thermogenesis and uncoupling protein-1 (UCP1) expression in white adipose; however, the mechanisms involved are
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