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Key Documents

COO/COA

SAB4300504

Anti-Connexin 43 Antibody

Name: Anti-Connexin 43 Antibody
Brand: SIGMA

rabbit polyclonal

Synonyme(s) :

Anti-CX43 antibody produced in rabbit, Anti-DFNB38 antibody produced in rabbit, Anti-GJAL antibody produced in rabbit, Anti-ODDD antibody produced in rabbit, Anti-gap junction protein, alpha 1, 43kDa antibody produced in rabbit

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About This Item

Numéro MDL:

MFCD00803532

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

product name

Anti-GJA1 (Ab-367) antibody produced in rabbit, affinity isolated antibody

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~43 kDa

Espèces réactives

rat, human, mouse

Concentration

1 mg/mL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

Isotype

IgG

Séquence immunogène

(R-A-S-S-R)

Numéro d'accès NCBI

NP_000156.1

Numéro d'accès UniProt

P17302

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... GJA1(2697)

Immunogène

Peptide sequence around aa. 365-369 (R-A-S-S-R), according to the protein GJA1.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling.

Shane A Lloyd et al.

Bone, 57(1), 76-83 (2013-07-31)

Connexin 43 (Cx43) is a gap junction protein that plays an integral role in the skeletal response to mechanical loading and unloading. In a previous study, we demonstrated preservation of trabecular bone mass and cortical bone formation rate in mice

Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis.

Shane A Lloyd et al.

BMC musculoskeletal disorders, 15, 122-122 (2014-04-11)

Connexin 43 (Cx43) is the predominant gap junction protein in bone. Mice with a bone-specific deletion of Cx43 (cKO) have an osteopenic cortical phenotype. In a recent study, we demonstrated that cKO mice are resistant to bone loss induced by

CD38/ADP-ribose/TRPM2-mediated nuclear Ca2+ signaling is essential for hepatic gluconeogenesis in fasting and diabetes.

So-Young Rah et al.

Experimental & molecular medicine, 55(7), 1492-1505 (2023-07-03)

Hepatic glucose production by glucagon is crucial for glucose homeostasis during fasting, yet the underlying mechanisms remain incompletely delineated. Although CD38 has been detected in the nucleus, its function in this compartment is unknown. Here, we demonstrate that nuclear CD38

Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing.

Alayna E Loiselle et al.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(1), 147-154 (2012-06-22)

Connexin43 (Cx43) plays an important role in osteoblastic differentiation in vitro, and bone formation in vivo. Mice with osteoblast/osteocyte-specific loss of Cx43 display decreased gap junctional intercellular communication (GJIC), bone density, and cortical thickness. To determine the role of Cx43

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