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SAB4200241

Sigma-Aldrich

Anti-PP2A subunit B isoform PR55-α antibody, Mouse monoclonal

clone 2G9, purified from hybridoma cell culture

Synonyme(s) :

Anti-B55α, Anti-PPP2R2A, Anti-PR52A, Anti-PR55A, Anti-Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform, Anti-Protein phosphatase 2, regulatory subunit B, alpha, B55A, Anti-Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.44

Le tarif et la disponibilité ne sont pas disponibles actuellement.

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified from hybridoma cell culture

Type de produit anticorps

primary antibodies

Clone

2G9, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen 50-55 kDa

Espèces réactives

rat, human, mouse

Concentration

~1.0 mg/mL

Technique(s)

immunohistochemistry: suitable
indirect immunofluorescence: suitable
western blot: 1-2 μg/mL using whole extracts of mouse 3T3, rat NRK or human HeLa cells

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Cet article
SAB1300598SAB1300599MABS270
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

species reactivity

rat, human, mouse

species reactivity

human

species reactivity

human

species reactivity

human, mouse

antibody form

purified from hybridoma cell culture

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

clone

2G9, monoclonal

clone

polyclonal

clone

polyclonal

clone

5A5-1F3, monoclonal

Gene Information

human ... PPP2R2A(5520)
mouse ... Ppp2r2a(71978)
rat ... Ppp2r2a(117104)

Gene Information

human ... PPP2R1A(5518)

Gene Information

human ... PPP2R1A(5518)

Gene Information

human ... PTPA(5524)

Description générale

Monoclonal Anti-PP2A subunit B isoform PR55- (mouse IgG1 isotype) is derived from the hybridoma 2G9 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of rat PP2A subunit B isoform PR55-. PP2A subunit B isoform PR55- (PPP2R2A) belongs to the phosphatase (PP)2A regulatory subunit B family. Protein phosphatase 2A is one of the major Ser/Thr phosphatases. PPP2R2A encodes an alpha isoform of the regulatory subunit B55 subfamily. This gene is mapped to human chromosome 8p21.2.

Spécificité

Monoclonal Anti- PP2A subunit B isoform PR55-α binds to rat, human and mouse PP2A subunit B isoform PR55-α. The antibody may also react with rat PP2A-B55-δ, human PP2A-B55-β and weakly associates with rabbit PP2A-B55-γ.

Application

Monoclonal Anti-PP2A subunit B isoform PR55-α antibody produced in mouse has been used in:
  • immunoblotting[1]
  • immunohistochemistry
  • immunofluorescence

Actions biochimiques/physiologiques

PP2A is a serine/threonine phosphatase that downregulates the MAP kinase pathway and subsequently modulates mitogenic signaling. This phosphatase also mediates cellular invasion, localization of Sgo1 at centromeres, cell movement, Ras-1 activation, and chromosome segregation. PP2A protein complex consists of a dimeric core containing subunits A and C; which in turn associates with the regulatory subunit B. PP2A subunit B is involved in the degranulation of mast cells . Monoclonal Anti- PP2A subunit B isoform PR55-α binds to rat, human and mouse PP2A subunit B isoform PR55-α. The antibody may also react with rat PP2A-B55-δ, human PP2A-B55-β and weakly associates with rabbit PP2A-B55-γ.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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    Consulter la Bibliothèque de documents

    Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer
    Liu W, et al.
    Neoplasia, 10(8) (2008)
    Jean-Marie Sontag et al.
    Journal of neurochemistry, 115(6), 1455-1465 (2010-11-04)
    Neuritic alterations are a major feature of many neurodegenerative disorders. Methylation of protein phosphatase 2A (PP2A) catalytic C subunit by the leucine carboxyl methyltransferase (LCMT1), and demethylation by the protein phosphatase methylesterase 1, is a critical PP2A regulatory mechanism. It
    Cihan S Erdogan et al.
    Chemico-biological interactions, 264, 52-60 (2017-01-22)
    Resveratrol (Resv), a natural polyphenol, is suggested to have various health benefits including improved insulin sensitivity. Resv activates Sirtuin (Sirt1) in several species and tissues. Sirt1 is a protein deacetylase with an important role in ageing, metabolism and β-cell function.
    Sunanda Basu
    Current protein & peptide science, 12(1), 3-11 (2010-12-31)
    Cell motility is a very critical phenomenon that plays an important role in the development of eukaryotic organisms. One of the well studied cell motility phenomena is chemotaxis, which is described as a directional movement of cell in response to
    Gregory Kranias et al.
    Cellular signalling, 22(12), 1882-1890 (2010-08-07)
    Asthma is characterised by antigen-mediated mast cell degranulation resulting in secretion of inflammatory mediators. Protein phosphatase 2A (PP2A) is a serine/threonine protein phosphatase composed of a catalytic (PP2A-C) subunit together with a core scaffold (PP2A-A) subunit and a variable, regulatory

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