SAB3500383
Anti-CXCR4 antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonyme(s) :
Anti-CXCR4
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About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
IgG fraction of antiserum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
mouse, human
Technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... CXCR4(7852)
Description générale
C-X-C motif chemokine receptor 4 (CXCR4) is encoded by the gene mapped to human chromosome 2q22.1. The gene codes for a protein with seven transmembrane regions. The encoded protein is expressed on the surface of T-cells, B-cells, monocytes, neutrophils and dendritic cells.
Immunogène
CXCR4 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human CXCR4.
Application
Anti-CXCR4 antibody produced in rabbit has been used in western blot analysis and indirect ELISA.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Actions biochimiques/physiologiques
C-X-C motif chemokine receptor 4 (CXCR4) is specific for stromal cell-derived factor-1. It plays a vital role in regulation of immune response in various immune cell types. CXCR4 interacts with CD4 (cluster of differentiation 4) and permits human immunodeficiency virus type 1 (HIV-1) entry and infection in to the cells. Polymorphism in the gene is associated with the development of Juvenile idiopathic arthritis (JIA). In addition, mutation in the gene increases the risk of susceptibility to cardiovascular diseases (CVDs).
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Liaison
The action of this antibody can be blocked using blocking peptide SBP3500383.
Forme physique
Supplied in PBS with 0.02% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
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Produit(s) apparenté(s)
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Description
Tarif
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Genetic variation of CXCR4 and risk of coronary artery disease: epidemiological study and functional validation of CRISPR/Cas9 system.
Runmin G, et al.
Oncotarget, 9(18), 14077?14083-14077?14083 (2018)
Deepika Nayak et al.
Journal of cell communication and signaling, 17(3), 609-626 (2022-11-04)
Cancer stem cells (CSCs) cause drug resistance in cancer due to its extensive drug efflux, DNA repair and self-renewal capability. ATP binding cassette subfamily G member 2 (ABCG2) efflux pump afford protection to CSCs in tumors, shielding them from the
Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model.
T Lai-Lei, et al.
Journal of Cancer Metastasis and Treatment, 2(1), 29-40 (2016)
Amber N Stratman et al.
Communications biology, 3(1), 734-734 (2020-12-06)
The preferential accumulation of vascular smooth muscle cells (vSMCs) on arteries versus veins during early development is a well-described phenomenon, but the molecular pathways underlying this polarization are not well understood. In zebrafish, the cxcr4a receptor (mammalian CXCR4) and its
Maciej Boleslaw Olszewski et al.
International journal of oncology, 54(4), 1168-1182 (2019-04-11)
Gain‑of‑function (GOF) mutations in the TP53 gene lead to acquisition of new functions by the mutated tumor suppressor p53 protein. A number of the over‑represented 'hot spot' mutations, including the ones in codons 175, 248 or 273, convey GOF phenotypes.
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