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Key Documents

SAB2700282

Sigma-Aldrich

Anti-GPC1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

FLJ38078, GPC1, glypican

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, human

Technique(s)

ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 500-3000

Numéro d'accès NCBI

NP_002072

Numéro d'accès UniProt

P35052

Application(s)

research pathology

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... GPC1(2817)

Description générale

Glypican 1 (GPC1) is located at 2q37.3 on the human chromosome. It belongs to the family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan. GPC1 is localized in the vascular system. GPC1 consists of an N-terminal secretory signal peptide, 14 conserved cysteine residues, a heparan sulfate (HS) attachment domain near the C terminus and a hydrophobic domain for attachment of the glycosylphosphatidylinositol (GPI) at the C terminus.

Immunogène

Recombinant protein encompassing a sequence within the center region of human Glypican 1.

Application

Anti-GPC1 antibody produced in rabbit has been used in flow cytometry and immunostaining.

Actions biochimiques/physiologiques

Glypican 1 (GPC1) plays an important role in cell growth, differentiation and morphogenesis. It also plays a role in cell migration, adhesion, anti-coagulation, lipoprotein metabolism and modulation of growth factors. GPC1 exhibits chaperone-like activity by restoring the binding activity of oxidized VEGF165 (vascular endothelial growth factors-165). Overexpression of GPC1 results in over accumulation of β-amyloid protein (Aβ) in the Alzheimer′s disease (AD) brain. Mutation in this gene is associated with Niemann-Pick C1 disease.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317,H412

Classification des risques

Aquatic Chronic 3 - Skin Sens. 1

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Glypican-1 as an Abeta binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer?s disease
Watanabe N, et al.
Faseb Journal, 18(9), 1013-1015 (2004)
Nelson S Yee et al.
Biomedicines, 8(12) (2020-12-11)
Pancreatic carcinoma (PC) is highly metastatic, and it tends to be detected at advanced stages. Identifying and developing biomarkers for early detection of PC is crucial for a potentially curative treatment. Extracellular vesicles (EVs) are bilayer lipid membrane-structured nanovesicles found
Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts
Mani K, et al.
Glycobiology, 16(8), 711-718 (2006)
Aikaterini Emmanouilidi et al.
Proteomics, 19(8), e1800158-e1800158 (2019-03-21)
Exosomes are small extracellular membrane vesicles important in intercellular communication, with their oncogenic cargo attributed to tumor progression and pre-metastatic niche formation. To gain an insight into key differences in oncogenic composition of exosomes, human non-malignant epithelial and pancreatic cancer
Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165
Gengrinovitch S, et al.
Test, 274(16), 10816-10822 (1999)
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