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Principaux documents

SAB2102031

Sigma-Aldrich

Anti-RNF31 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-FLJ10111, Anti-FLJ23501, Anti-MGC19975, Anti-Ring finger protein 31, Anti-ZIBRA

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Poids mol.

120 kDa

Espèces réactives

rabbit, guinea pig, rat, human

Conditionnement

pkg of 100 μL buffered aqueous solution
pkg of 50 μg lyophilized powder

Concentration

0.5 mg - 1 mg/mL

Technique(s)

western blot: suitable

Numéro d'accès UniProt

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... RNF31(55072)

Catégories apparentées

Immunogène

Synthetic peptide directed towards the middle region of human RNF31

Application

Anti-RNF31 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Actions biochimiques/physiologiques

PWP2 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.

Séquence

Synthetic peptide located within the following region: SLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLLQKL

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
Kato K
PLoS ONE, 8(10), 1-9 (2013)
SPATA2 links CYLD to the TNF-? receptor signaling complex and modulates the receptor signaling outcomes.
Wagner SA
The Embo Journal, 35(17), 1868-1884 (2016)
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nakazawa S
Nature Communications, 7:12547, 1-14 (2016)
Kouki Hoshino et al.
Scientific reports, 14(1), 346-346 (2024-01-04)
RNF31 is a multifunctional RING finger protein implicated in various inflammatory diseases and cancers. It functions as a core component of the linear ubiquitin chain assembly complex (LUBAC), which activates the nuclear factor kappaB (NF-κB) pathway via the generation of
Seshiru Nakazawa et al.
Nature communications, 7, 12547-12547 (2016-08-25)
Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the UBAN domain of OPTN reportedly abolishes its NF-κB suppressive activity, the precise molecular basis in ALS pathogenesis still remains unclear.

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