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Principaux documents

SAB1402151

Sigma-Aldrich

Monoclonal Anti-COL1A1 antibody produced in mouse

clone 3G3, purified immunoglobulin, buffered aqueous solution

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

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Source biologique

mouse

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

3G3, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~35.79 kDa

Espèces réactives

human, mouse

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

Comparer avec des articles similaires

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1 of 4

Cet article
SAB4200678C2456SAB1403684
conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

unconjugated

species reactivity

human, mouse

species reactivity

pig, rat, human, deer, bovine

species reactivity

bovine, human, pig, rat, rabbit, deer

species reactivity

human

Gene Information

human ... COL1A1(1277)

Gene Information

human ... COL1A1(1277)

Gene Information

rat ... Col1a1(29393)

Gene Information

human ... COL2A1(1280)

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

ascites fluid

antibody form

purified immunoglobulin

clone

3G3, monoclonal

clone

COL-1, monoclonal

clone

COL-1, monoclonal

clone

1E1, monoclonal

Description générale

The COL1A1 (collagen type I α 1 chain) gene codes for the pro-α1 chains of type I collagen. The triple helix of the type I collagen is composed of two α chains and this protein is localized to connective tissues and predominantly expressed in bone, cornea, dermis and tendon. COL1A1 is mapped to human chromosome 17q21.33. 90% of the bone matrix comprises of collagen type I.

Immunogène

COL1A1 (NP_000079.1, 1021 a.a. ~ 1108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
EGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIK

Actions biochimiques/physiologiques

Proteins belonging to the collagen family, supports and nourishes body tissues such as tendons, cartilage, skin, and sclera of the eye. Mutation in COL1A1 (collagen type I α 1 chain) gene is associated with a number of connective tissue disorders such as Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, osteogenesis imperfecta types I-IV, idiopathic osteoporosis and Caffey Disease. The COL1A1 is associated with a particular type of skin tumor called dermatofibrosarcoma protuberans which is due to over expression of growth factors. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Forme physique

Solution in phosphate buffered saline, pH 7.4

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Epidemiology, genetics and treatments for myopia.
Yu L, et al.
International journal of ophthalmology, 4(6), 658-658 (2011)
Aspek Klinik, Genetik dan Molekuler Osteogensis Imperfekta.
Mariska M and Auerkari E I
Journal of Dentistry, 14(2), 95-110 (2015)
Clinical utility gene card for: Ehlers?Danlos syndrome types I?VII and variants-update 2012.
Mayer K, et al.
European Journal of Human Genetics, 21(1) (2013)
Nicolas R Chevalier et al.
Communications biology, 4(1), 770-770 (2021-06-25)
While the colonization of the embryonic gut by neural crest cells has been the subject of intense scrutiny over the past decades, we are only starting to grasp the morphogenetic transformations of the enteric nervous system happening in the fetal
Masamichi Hayashi et al.
BMC cancer, 14, 108-108 (2014-02-21)
Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death especially among Asian and African populations. It is urgent that we identify carcinogenesis-related genes to establish an innovative treatment strategy for this disease. Triple-combination array analysis was performed

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