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S9012

Sigma-Aldrich

Sulforhodamine B sodium salt

Powder

Synonyme(s) :

Acid red 52; Acid Rhodamine B

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About This Item

Formule empirique (notation de Hill):
C27H29N2NaO7S2
Numéro CAS:
3520-42-1
Poids moléculaire :
580.65
Numéro C.I. (Colour Index):
45100
Numéro Beilstein :
3886008
Numéro CE :
222-529-8
Numéro MDL:
MFCD00010180
Code UNSPSC :
12171500
ID de substance PubChem :
24899824
Nomenclature NACRES :
NA.47

product name

Sulforhodamine B sodium salt, Technical grade

Niveau de qualité

200

Forme

powder

Composition

Dye content, ~75%

εmax

≥85000 at 554-560 nm

Application(s)

diagnostic assay manufacturing
hematology
histology

Température de stockage

room temp

Chaîne SMILES 

[Na+].CCN(CC)c1ccc2c(OC3=CC(\C=CC3=C2c4ccc(cc4S([O-])(=O)=O)S([O-])(=O)=O)=[N+](\CC)CC)c1

InChI

1S/C27H30N2O7S2.Na/c1-5-28(6-2)18-9-12-21-24(15-18)36-25-16-19(29(7-3)8-4)10-13-22(25)27(21)23-14-11-20(37(30,31)32)17-26(23)38(33,34)35;/h9-17H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1

Clé InChI

SXQCTESRRZBPHJ-UHFFFAOYSA-M

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Description générale

Sulforhodamine B (also known as SRB, kiton rhodamine B, lissamine rhodamine B, or sulphorhodamine B) is a bright-pink anionic, aminoxanthene dye carrying two sulfonate substituents.

Application

Sulforhodamine B (SRB) is known for use in SRB assay for the determination of in vitro cytotoxicity through staining and the observation of live cells, proliferation and drug screening.

It has been used in the SRB assay to evaluate the effect of mouthwashes on protein content in primary cultures of human fibroblasts.

It is also suitable as a microscopic tracer for the assessment of blood-brain barrier integrity by post mortem inspection of frozen sections. SRB is useful as a caries detector dye with subsequent inspection of histological material.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Gang Chen et al.
Cancer research, 74(16), 4536-4548 (2014-06-21)
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Samantha N Andrews et al.
Pharmaceutical research, 30(4), 1099-1109 (2012-12-01)
Most methods to increase transdermal drug delivery focus on increasing stratum corneum permeability, without addressing the need to increase permeability of viable epidermis. Here, we assess the hypothesis that viable epidermis offers a significant permeability barrier that becomes rate limiting
Xinyuan Chen et al.
Journal of controlled release : official journal of the Controlled Release Society, 159(1), 43-51 (2012-01-21)
Full-surface laser ablation has been shown to efficiently disrupt stratum corneum and facilitate transcutaneous drug delivery, but it is frequently associated with skin damage that hampers its clinic use. We show here that a safer ablative fractional laser (AFL) can
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Biomedicines, 9(1) (2021-01-21)
Sigma (σ) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (σ1) and sigma-2 (σ2). Both σ receptor
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