S4441

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

• Synonyme(s) : 1-Isothiocyanato-4-(methylsulfinyl)-butane
• Formule empirique (notation de Hill): C₆H₁₁NOS₂
• Numéro CAS: 4478-93-7
• Poids moléculaire : 177.29
• Numéro MDL: MFCD00198068
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724610
• Nomenclature NACRES : NA.77

Propriétés

• product name: DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
• Source biologique: synthetic
• Niveau de qualité: 200
• Pureté: ≥90% (HPLC)
• Forme: liquid
• Solubilité: DMSO: soluble 40 mg/mL; H₂O: insoluble
• Compatibilité: for use with ABI 7500
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
• Clé InChI: SUVMJBTUFCVSAD-UHFFFAOYSA-N

Description

Application

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Actions biochimiques/physiologiques

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)