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S3567

Sigma-Aldrich

SB 415286

≥98% (HPLC)

Synonyme(s) :

3-[(3-Chloro-4-hydroxyphenyl)­amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione

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About This Item

Formule empirique (notation de Hill):
C16H10N3O5Cl
Numéro CAS:
264218-23-7
Poids moléculaire :
359.72
Numéro MDL:
MFCD04039789
Code UNSPSC :
12352200
ID de substance PubChem :
24278412
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Couleur

yellow to orange

Solubilité

DMSO: 5 mg/mL, clear
H2O: insoluble

Auteur

GlaxoSmithKline

Température de stockage

−20°C

Chaîne SMILES 

Oc1ccc(NC2=C(C(=O)NC2=O)c3ccccc3[N+]([O-])=O)cc1Cl

InChI

1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)

Clé InChI

PQCXVIPXISBFPN-UHFFFAOYSA-N

Informations sur le gène

human ... GSK3A(2931) , GSK3B(2932)

Application

SB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.

Actions biochimiques/physiologiques

SB 415286 is a small molecule inhibitor of GSK-3 in muscle and fat cells. SB 415286 induces activation of glycogen synthase and regulates the transport glucose. SB 415286 reduces the systemic inflammation induced by endotoxic shock in rat model of acute colitis. It increases the axonal growth and promotes the recovery of injured adult CNS neurons. SB 415289 is implicated in inducing chromosome instability when used as therapeutic agents.
Glycogen synthase kinase-3 (GSK-3) inhibitor.

Caractéristiques et avantages

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations légales

Sold for research purposes under agreement from GlaxoSmithKline.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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PD 98,059 solid

Sigma-Aldrich

P215

PD 98,059

Adsorbant Carbopack™ matrix Carbopack™ B, 60-80 mesh, bottle of 10 g

Supelco

20273

Adsorbant Carbopack™

SB 431542 hydrate ≥98% (HPLC), powder

Sigma-Aldrich

S4317

SB 431542 hydrate

Adsorbant Carboxen® matrix Carboxen® 1000, 60-80 mesh, bottle of 10 g

Supelco

10478-U

Adsorbant Carboxen®

CHIR99021 ≥98% (HPLC)

Sigma-Aldrich

SML1046

CHIR99021

Pepstatine A microbial, ≥90% (HPLC)

Sigma-Aldrich

P5318

Pepstatine A

Jorge-Tonatiuh Ayala-Sumuano et al.
Scientific reports, 1, 178-178 (2012-02-23)
Adipogenesis is regulated by a complex cascade of transcriptional factors, but little is known about the early events that regulate the adipogenic program. Here, we report the role of the srebf1a gene in the differentiation of fibroblastic 3T3-F442A cells. We
Brendan J R Whittle et al.
British journal of pharmacology, 147(5), 575-582 (2005-11-30)
The effects of the inhibitors of glycogen synthase kinase-3beta (GSK-3beta), TDZD-8 and SB 415286, which can substantially reduce the systemic inflammation associated with endotoxic shock in vivo, have now been investigated on the acute colitis provoked by trinitrobenzene sulphonic acid
Daniela Hulcová et al.
Molecules (Basel, Switzerland), 23(4) (2018-03-22)
Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism. It plays a key role in diverse physiological processes including metabolism, the cell cycle, and gene
Javier G Pizarro et al.
Journal of cellular and molecular medicine, 13(9B), 3906-3917 (2008-07-16)
Pharmacological GSK-3 inhibitors are potential drugs for the treatment of neurodegenerative diseases, cancer and diabetes. We examined the antiproliferative effects of two GSK-3 inhibitors, lithium and SB-415286, on B65 neuroblastoma cell line. Treatment of B65 cells with either drug administered
Jocelyn R Barnes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(14), 2793-2807 (2020-02-28)
The spatiotemporal dynamics of excitatory neurotransmission must be tightly regulated to achieve efficient synaptic communication. By limiting spillover, glutamate transporters are believed to prevent excessive activation of extrasynaptically located receptors that can impair synaptic plasticity. While glutamate transporter expression is
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