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Key Documents

S0292

Sigma-Aldrich

Silymarin

flavonolignans

Synonyme(s) :

flavolignans

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About This Item

Numéro CAS:
65666-07-1
Numéro MDL:
MFCD01776359
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.81

Source biologique

plant (Silybum marianum)

Niveau de qualité

200

Forme

powder

Technique(s)

toxicology assay: suitable

Application(s)

microbiology

Température de stockage

−20°C

InChI

1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

Clé InChI

SEBFKMXJBCUCAI-UHFFFAOYSA-N

Description générale

Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

Application

Silymarin has been used to study:
  • its in vitro antiviral, antibacterial, antifungal activities and cytotoxicity
  • its effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model
  • its effect on liver toxication induced by Fumonisin B1 in mice

Actions biochimiques/physiologiques

Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.
Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.
Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin.

Autres remarques

Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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USP

USP

1309911

Powdered Holy Basil Extract

Isosilybin (A + B mixture) phyproof® Reference Substance

PHL89231

Isosilybin (A + B mixture)

Effect of silymarin on bladder overactivity in cyclophosphamide-induced cystitis rat model
Eser N, et al.
Phytomedicine, 19(8-9), 840-845 (2012)
Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals.
Eminzade, S.
Nutrition & Metabolism, 5, 18-18 (2008)
Laise Mara Oliveira Miranda et al.
Biomedical and environmental sciences : BES, 33(9), 690-700 (2020-10-28)
To evaluate the efficiency of silymarin (SMN) in modulating metabolic parameters and redox status in rats with type 1 diabetes mellitus (T1DM). Diabetes was induced by intraperitoneal injection of alloxan. The diabetic rats were administered with SMN at doses of
Sirajudheen Anwar et al.
Indian journal of pharmacology, 50(3), 108-115 (2018-09-01)
Silymarin, extracted from the seeds of Silybum marianum L. (Milk thistle), is traditionally used for treating various illnesses such as diabetes, cancer, inflammation, hepatitis, liver cirrhosis, and renal problems. Acute cytotoxicity and genotoxicity studies have been reported with ambiguous outcomes;
Verônica de Souza Santos et al.
Life sciences, 228, 305-315 (2019-05-03)
Silymarin, an extract from Silybum marianum (milk thistle) containing a standardized mixture of flavonolignans that ameliorates some types of liver disease and, more recently, kidney damage, could be used for the ROS-scavenging effect of these antioxidants. Furthermore, contrast-induced nephropathy (CIN)
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