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RAB0105

Sigma-Aldrich

Human Cystatin C ELISA Kit

for serum, plasma, cell culture supernatant and urine

Synonyme(s) :

Cystatin-3, Cystatin-C

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About This Item

Code UNSPSC :
41116158
Nomenclature NACRES :
NA.32

Espèces réactives

human

Conditionnement

kit of 96 wells (12 strips x 8 wells)

Technique(s)

ELISA: suitable
capture ELISA: suitable

Entrée

sample type plasma
sample type urine
sample type serum
sample type cell culture supernatant(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 300 pg/mL
standard curve range: 0.313-20 ng/mL

Méthode de détection

colorimetric

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... CST3(1471)

Catégories apparentées

Description générale

The Human Cystatin C ELISA (enzyme-linked immunosorbent assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human cystatin C in serum, plasma, cell culture supernatants and urine.

Immunogène

Recombinant Human CystatinC

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Actions biochimiques/physiologiques

Cystatin C (CysC) is released by all nucleated cells. Abnormal thyroid function, immunosuppressive therapy and systemic inflammation alter the levels of CysC. Mutation in the gene encoding CysC causes hereditary cystatin C amyloid angiopathy, which is a consequence of amyloid deposits containing the CysC variant in the brain.
Cystatin-C precursor (CST3) is an inhibitor of lysosomal cysteine proteases and several cathepsins like cathepsin S, a lysosomal enzyme. It has been shown that CST3 is a marker of glomerular filtration and diabetic kidney disease. In the presence of pathological conditions, it forms amyloid fibrils in brain arteries. Mutations in the gene encoding CST3 have been shown to be associated with a form of amyloidosis and age-related macular degeneration.

Autres remarques

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Composants de kit également disponibles séparément

Réf. du produit
Description
FDS
  • RABELADEELISA 5X Assay/Sample Diluent Buffer E (Item E2)FDS
  • RABSTOP3ELISA Stop Solution (Item I)FDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)FDS
  • RABWASH420X Wash Buffer (Item B)FDS

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Warning

Mentions de danger

H290

Conseils de prudence

P234 - P390

Classification des risques

Met. Corr. 1

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Critical Care Nephrology, 254-254 (2009)
Assessing validity of serum cystatin C for predicting metabolic syndrome.
Asefy Z et.al.
Pakistan journal of biological sciences: PJBS, 17(4), 582-585 (2014)
Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function, 254-254 (2009)
Yuanyuan Pei et al.
European journal of medical research, 27(1), 39-39 (2022-03-12)
Acute kidney injury (AKI) is a common and critical complication of sepsis, and is associated with unacceptable morbidity and mortality. Current diagnostic criteria for AKI was insensitive for early detection. Novel biomarkers including cystatin C, kidney injury molecule-1 (KIM-1), neutrophil
Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases.
Levy E et.al.
The Journal of Experimental Medicine, 169(5), 1771-1778 (1989)
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