RAB0026
Human BDNF ELISA Kit
for serum, plasma, cell culture supernatant and urine
Synonyme(s) :
BDNF, Brain-derived neurotrophic factor
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About This Item
Code UNSPSC :
41116158
Nomenclature NACRES :
NA.32
Produits recommandés
Espèces réactives
human
Conditionnement
kit of 96 wells (12 strips x 8 wells)
Technique(s)
ELISA: suitable
capture ELISA: suitable
Entrée
sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 0.066-16 ng/mL
Méthode de détection
colorimetric
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
human ... BDNF(627)
Description générale
The Human BDNF ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BDNF in serum, plasma, cell culture supernatants and urine.
The brain derived neurotrophic factor (BDNF) gene is mapped to human chromosome 11p14.1. BDNF is a member of the neurotrophin family of growth factors. The gene encodes a precursor protein, proBDNF. Mature BDNF (mBDNF) is synthesized by post-translational cleavage of proBDNF. Both proBDNF and mBDNF play crucial roles in cellular signaling.
Immunogène
Recombinant Human BDNF
Application
For research use only. Not for use in diagnostic procedures.
Human BDNF ELISA kit has been used to determine the effect of bone marrow mesenchymal stem cell (MSC) transplantation on BDNF protein expression in the striatum of Tourette syndrome (TS) rats. It has also been used to determine the plasma BDNF levels in GD1 (Gaucher′s disease type 1) patients and control population.
Human BDNF ELISA kit has been used to determine the effect of bone marrow mesenchymal stem cell (MSC) transplantation on BDNF protein expression in the striatum of Tourette syndrome (TS) rats. It has also been used to determine the plasma BDNF levels in GD1 (Gaucher′s disease type 1) patients and control population.
Human BDNF ELISA Kit has been used:
- to measure the brain-derived neurotrophic factor (BDNF) protein expression
- to determine BDNF level in the slice culture medium and the extracts of organotypic brain slice cultures (OBSCs)
- to determine BDNF level in plasma
Actions biochimiques/physiologiques
Brain derived neurotrophic factor (BDNF) is involved in hippocampal function and verbal episodic memory in humans. Hence, variation in the BDNF gene expression alters these neurological functions. BDNF also plays a vital role in vascular function and participates in angiogenesis via the specific receptor tropomyosin-related kinase B (TrkB). It is involved in the pathogenesis of Alzheimer′s disease. ProBDNF interacts with p75 neurotrophin receptor, leading to long-term depression in the hippocampus.
Autres remarques
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Composants de kit également disponibles séparément
Réf. du produit
Description
FDS
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Met. Corr. 1
Code de la classe de stockage
8A - Combustible corrosive hazardous materials
Certificats d'analyse (COA)
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