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Merck
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Key Documents

PZ0196

Sigma-Aldrich

Tenidap

≥97% (HPLC)

Synonyme(s) :

(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide, CP 66248

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About This Item

Formule empirique (notation de Hill):
C14H9ClN2O3S
Numéro CAS:
120210-48-2
Poids moléculaire :
320.75
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥97% (HPLC)

Forme

powder

Couleur

faintly yellow to dark yellow

Solubilité

DMSO: 1 mg/mL, clear (warmed)

Température de stockage

2-8°C

InChI

1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)

Clé InChI

IZSFDUMVCVVWKW-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Tenidap is an anti-inflammatory and anti-rheumatic with a variety of activities. Tenidap preferentially inhibits COX-1 with an IC50 value of 30 nM, and also has some lesser inhibitory activity towards COX-2 and 5-lipoxygenase (IC50 values are 1.2 and > 30 μM for COX-2 and 5-lipoxygenase respectively). Tenidap is also a cytokine modulator, an opener of inward rectifying hKIR2.3 channels (EC50 = 402 nM) and has been shown to modulate cytoplasmic pH and inhibit anion transport in vitro.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

J M Sanz et al.
European journal of pharmacology, 355(2-3), 235-244 (1998-10-06)
Tenidap is an anti-inflammatory drug whose mechanism of action is not fully understood. It has been shown to block plasma membrane anion transport and to decrease release of interleukin-1beta, probably via the inhibition of interleukin-1beta converting enzyme. In the present
O Ducoudret et al.
Pflugers Archiv : European journal of physiology, 442(5), 709-717 (2001-08-21)
In the present experiments we expressed the rat kidney Na+-HCO3- cotransporter (rkNBC) in Xenopus laevis oocytes to reinvestigate the flux coupling ratio under improved measuring conditions. Essentially the current/voltage (I/V) relationship of isolated inside-out giant membrane patches was measured and
S Müller-Berger et al.
Pflugers Archiv : European journal of physiology, 442(5), 718-728 (2001-08-21)
The Na+-HCO3- cotransporter of rat kidney (rkNBC) was expressed in Xenopus laevis oocytes to test whether cytosolic Ca2+ ([Ca2+]i) affects the cotransport stoichiometry. The current/voltage relationship of giant inside-out membrane patches of rkNBC-expressing oocytes was measured at near-physiological Na+ and
C Ribbens et al.
The Journal of rheumatology, 27(4), 888-893 (2000-04-27)
To demonstrate that serum matrix metalloproteinase-3 (MMP-3) is a variable associated with disease activity and with the response to treatment in rheumatoid arthritis (RA). Serum MMP-3 levels were measured and compared to biological and clinical disease activity variables in 20
E Alzola et al.
Cellular signalling, 13(7), 465-473 (2001-08-23)
We have compared the formation of pores in rat submandibular acinar cells in response to 2',3'-O-(4-benzoylbenzoyl) adenosine 5'-triphosphate (Bz-ATP) and maitotoxin. Bz-ATP (100 microM) permeabilized the cells to ethidium bromide. The uptake of ethidium increased to 29+/-1% of maximal uptake
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