P8390

Picrotoxinin

• Formule empirique (notation de Hill): C₁₅H₁₆O₆
• Numéro CAS: 17617-45-7
• Poids moléculaire : 292.28
• Numéro MDL: MFCD00078765
• Code UNSPSC : 41116107
• ID de substance PubChem : 24898746
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Niveau de qualité: 200
• Chaîne SMILES: [H][C@@]12OC(=O)[C@]([H])([C@@H]1C(C)=C)[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@@]2([H])[C@]35C
• InChI: 1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8+,9-,10-,13-,14-,15+/m1/s1
• Clé InChI: PIMZUZSSNYHVCU-KBLUICEQSA-N

Description

Description générale

Picrotoxinin is a component of picrotoxin[1] and can be derived from plants. It is a non-nitrogenous compound.[2]

Application

Picrotoxinin has been used as an agonist of taste 2 receptor member 14 (TAS2R14) to perform an array-based bitter receptor screening assay[3] and to study the effect of calcium buffering and calcium sensor type on its sensitivity.[4]

Actions biochimiques/physiologiques

GABA_A receptor antagonist; binds to the GABA receptor-linked Cl⁻ channel.

Picrotoxinin acts as a potent convulsant.[1]

Caractéristiques et avantages

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Autres remarques

Active component of picrotoxin

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300
• Conseils de prudence: P301 + P310 + P330
• Classification des risques: Acute Tox. 2 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges