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P1584

Sigma-Aldrich

Peptidyl Arginine Deiminase from rabbit skeletal muscle

buffered aqueous glycerol solution, ≥200 units/mg protein (Bradford)

Synonyme(s) :

Protein arginine iminohydrolase

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About This Item

Numéro CAS:
75536-80-0
Numéro de classification (Commission des enzymes):
3.5.3.15 (BRENDA, IUBMB)
Numéro MDL:
MFCD00165226
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Forme

buffered aqueous glycerol solution

Niveau de qualité

300

Activité spécifique

≥200 units/mg protein (Bradford)

Maladie(s) pertinente(s)

arthritis (rheumatoid )

Conditions d'expédition

dry ice

Température de stockage

−70°C

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Description générale

Peptidyl arginine deiminase is the enzyme that converts arginine into citrulline.

Application

Peptidyl arginine deiminase has been used in a study that assessed promising novel biomarkers for the early diagnosis of rheumatoid arthritis. It has also been used in a study to investigate the autopathogenic correlation of periodontitis and rheumatoid arthritis.

Actions biochimiques/physiologiques

Calcium is required for peptidylarginine deiminase activity in vitro.

Définition de l'unité

One unit will produce 1 μmole of N-α-benzoylcitrulline ethyl ester from BAEE per hr at 55 °C at pH 7.2.

Forme physique

Solution in 20 mM Tris-HCl, pH 7.4, containing 10 mM 2-mercaptoethanol, 1 mM EDTA and 10% glycerol

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H334

Conseils de prudence

P261 - P284 - P501

Classification des risques

Resp. Sens. 1

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Leendert A Trouw et al.
Autoimmunity reviews, 12(2), 318-322 (2012-06-06)
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and damage of the joints affecting about 0.5% of the general population. Early treatment in RA is important as it can prevent disease progression and irreversible damage of the
John G Routsias et al.
Rheumatology (Oxford, England), 50(7), 1189-1193 (2011-02-24)
Recently, a number of studies have pointed to a potential relationship between periodontitis (PO) and RA and vice versa. Both diseases are characterized by chronic inflammation, osseous destruction, damage of the supporting soft tissues, similar cellular immune responses and common
Murat Bozdag et al.
Bioorganic & medicinal chemistry letters, 23(3), 715-719 (2012-12-26)
Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non
Joyce J B C van Beers et al.
Biochimie, 95(2), 299-308 (2012-10-03)
Citrullination, the conversion of peptidylarginine to peptidylcitrulline is catalyzed by peptidylarginine deiminases (PAD). The expression of PAD isoforms displays great variation among different tissues as demonstrated by PAD mRNA analyses. Here we have analyzed the differential expression of PAD2, PAD4
Isabelle Auger et al.
Arthritis and rheumatism, 62(1), 126-131 (2009-12-30)
Autoantibodies to citrullinated proteins are specific for rheumatoid arthritis (RA) and recognize epitopes centered by citrulline, a posttranslationally modified form of arginine. Peptidyl arginine deiminase type 4 (PAD-4), the enzyme that converts arginine into citrulline, is in itself a target
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