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P0763

Sigma-Aldrich

1,2-Dipalmitoyl-sn-glycero-3-phosphocholine

semisynthetic, ≥99%

Synonyme(s) :

PC, (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]- 3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt, 1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine, 1,2-Dihexadecanoyl-sn-glycero-3-phosphorylcholine, 1,2-Dipalmitoyl-sn-glycero-3-phosphorylcholine, 1,2-Dipalmitoyl-L-lecithin, L-α-Phosphatidylcholine, dipalmitoyl, L-β,γ-Dipalmitoyl-α-lecithin, DPPC, PC(16:0/16:0)

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About This Item

Formule empirique (notation de Hill):
C40H80NO8P
Numéro CAS:
63-89-8
Poids moléculaire :
734.04
Numéro CE :
200-567-6
Numéro MDL:
MFCD00036903
Code UNSPSC :
12352211
ID de substance PubChem :
24898128
Nomenclature NACRES :
NA.25

Source biologique

semisynthetic

Niveau de qualité

200

Pureté

≥99%

Forme

powder

Groupe fonctionnel

phospholipid

Type de lipide

phosphoglycerides

Conditions d'expédition

ambient

Température de stockage

−20°C

Chaîne SMILES 

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1

Clé InChI

KILNVBDSWZSGLL-KXQOOQHDSA-N

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Application


  • Effects induced by η(6)-p-cymene ruthenium(II) complexes on Langmuir monolayers mimicking cancer and healthy cell membranes do not correlate with their toxicity.: This study explores the impact of η(6)-p-cymene ruthenium(II) complexes on Langmuir monolayers, including 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), to model cancer and healthy cell membranes, revealing insights into membrane interactions and cytotoxicity mechanisms (Wrobel et al., 2024).

  • Interaction of L-phenylalanine with carbonyl groups in mixed lipid membranes.: This research examines the interaction of L-phenylalanine with carbonyl groups in mixed lipid membranes, incorporating DPPC, to understand the role of amino acids in membrane dynamics and stability (Brandan et al., 2024).

  • Spatial Arrangement of the Drug Ibuprofen in a Model Membrane in the Presence of Lipid Rafts.: The study investigates the spatial arrangement of ibuprofen within a model membrane containing lipid rafts, with DPPC as a component, shedding light on drug-membrane interactions and the role of lipid rafts in drug delivery (Kashnik et al., 2024).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Johannes Thoma et al.
Chemical communications (Cambridge, England), 48(70), 8811-8813 (2012-07-28)
We present a model system to demonstrate that the positioning of biomolecules (membrane proteins) in a nonnative, complex thin film environment can be regulated by the phase behavior of film components. Partial separation between an amphiphilic polymer and a lipid
Edyta Paszko et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 202-210 (2012-11-20)
Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol (PEG)-grafted, transferrin (Tf)-conjugated liposome formulations of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (Foscan)
Fernando R Moya et al.
Pediatrics, 115(4), 1018-1029 (2005-04-05)
Evidence suggests that synthetic surfactants consisting solely of phospholipids can be improved through the addition of peptides, such as sinapultide, that mimic the action of human surfactant protein-B (SP-B). A synthetic surfactant containing a mimic of SP-B may also reduce
John M Franck et al.
Journal of the American Chemical Society, 135(11), 4175-4178 (2013-01-26)
The translational hydration dynamics within 0.5-1.5 nm of the surface of a DPPC liposome, a model biomacromolecular surface, is analyzed by the recently developed Overhauser dynamic nuclear polarization (ODNP) technique. We find that dramatic changes to the bulk solvent cause
Julien Perino et al.
Antiviral research, 89(1), 89-97 (2010-11-26)
Vaccinia virus (VACV) was used as a surrogate of Variola virus (genus Orthopoxvirus), the causative agent of smallpox, to study orthopoxvirus infection via the respiratory airway. Lung surfactant, a physiological barrier to infection encountered by the virus, is predominantly composed
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