P0358

Anti-Potassium Channel K_v4.3 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonyme(s) : Anti-BRGDA9, Anti-KCND3L, Anti-KCND3S, Anti-KSHIVB, Anti-KV4.3, Anti-SCA19, Anti-SCA22
• Numéro MDL: MFCD02097221
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: lyophilized powder
• Espèces réactives: rat, human
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot (chemiluminescent): 1:200
• Numéro d'accès UniProt: Q9UK17
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... KCND3(3752) ; rat ... Kcnd3(65195)

Description

Description générale

Potassium voltage-gated channel subfamily D member 3 (KCND3) gene codes for Kv4.3, an α-subunit of the I_to channel. It has seven exons and is mapped to the human chromosome 1p13.2. Kv4.3 is expressed in the brain and the heart. Anti-potassium channel Kv4.3 recognizes Kv4.3 protein in the rat by immunoblotting.

Immunogène

synthetic peptide corresponding to amino acids 451-468 of rat or human potassium channel K_v4.3 (with additional N-terminal tyrosine and methionine replaced with norleucine).

Application

Anti-Potassium Channel Kv4.3 antibody produced in rabbit has been used in immunohistochemistry.

Actions biochimiques/physiologiques

Potassium channels contribute to maintaining cell volume, neuronal excitability, and the secretion of transmitters, salt, and hormones. Potassium voltage-gated channel subfamily D member (Kv4.3) is involved in membrane repolarization in excitable cells. Kv4.3 may participate in the development of the cerebellum. It is capable of forming homo- or hetero-tetramers with the Shal subfamily channel members. KCND3 gene mutations result in Brugada syndrome and spinocerebellar ataxia type 22.

Forme physique

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H312 + H332,H412
• Conseils de prudence: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable