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P0275

Sigma-Aldrich

Poly(Glu, Tyr) sodium salt

greener alternative

Glu:Tyr (4:1), mol wt 20,000-50,000

Synonyme(s) :

L-Glutamic acid sodium salt (1:1) polymer with L-tyrosine

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About This Item

Numéro CAS:
97105-00-5
Numéro MDL:
MFCD00148022
Code UNSPSC :
12352209
Nomenclature NACRES :
NA.26

Forme

powder

Niveau de qualité

200

Ratio alimentaire

Glu:Tyr (4:1)

Poids mol.

20,000-50,000

Score du produit alternatif plus écologique

old score: 48
new score: 45
Find out more about DOZN™ Scoring

Caractéristiques du produit alternatif plus écologique

Safer Solvents and Auxiliaries
Design for Energy Efficiency
Reduce Derivatives
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

Couleur

white to off-white

Autre catégorie plus écologique

, Re-engineered

Température de stockage

−20°C

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Catégories apparentées

Description générale

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Safer Solvents and Auxiliaries”, “Enhanced Energy Efficiency” and “Reduced Derivative”. Click here to view its DOZN scorecard.

Application

Poly(Glu, Tyr) sodium salt has been used as a substrate for
  • janus kinase 3 (JAK3) in enzyme linked immunosorbent assay (ELISA)-based assay
  • proto-oncogene tyrosine-protein kinase (Src) and zeta chain of T cell receptor associated protein kinase 70 (Zap70)
  • in in vitro tyrosine kinase assay

Actions biochimiques/physiologiques

Poly(glu, tyr) sodium salt is a polyamino acid with applications in cancer research.

Remarque sur l'analyse

Molecular weight based on viscosity. Also assayed by MALLS.

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

A simple and robust automated kinase profiling platform using luminescent ADP accumulation technology
Larson B, et al.
Assay and Drug Development Technologies, 7(6), 573-584 (2009)
Dimerization of the Pragmin pseudo-kinase regulates protein tyrosine phosphorylation
Lecointre C, et al.
Structure, 26(4), 545-554 (2018)
Identification of Chinese Herbal Compounds with Potential as JAK3 Inhibitors
Su D, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM (2019)
Jiaye Guo et al.
Biochemistry, 57(32), 4934-4951 (2018-07-06)
Human epidermal growth factor receptor 2 (HER2) is a validated breast cancer drug target for small molecule inhibitors that target the ATP-binding pocket of the kinase domain. In this work, a large-scale virtual screen was performed to a novel homology
C J Bruns et al.
Cancer research, 60(11), 2926-2935 (2000-06-13)
We determined whether down-regulation of the epidermal growth factor-receptor (EGF-R) signaling pathway by oral administration of a novel EGF-R tyrosine kinase inhibitor (PKI166) alone or in combination with gemcitabine (administered i.p.) can inhibit growth and metastasis of human pancreatic carcinoma
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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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