Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

View All Documentation

P0032

Sigma-Aldrich

Pyr3

≥98% (HPLC)

Synonyme(s) :

Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C16H11Cl3F3N3O3
Poids moléculaire :
456.63
Numéro MDL:
MFCD00178741
Code UNSPSC :
12352200
ID de substance PubChem :
329819985
Nomenclature NACRES :
NA.25

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: 20 mg/mL, clear

Température de stockage

2-8°C

Chaîne SMILES 

CCOC(=O)c1cnn(-c2ccc(NC(=O)\C(Cl)=C(\Cl)Cl)cc2)c1C(F)(F)F

InChI

1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)

Clé InChI

RZHGONNSASQOAY-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Pyr3 is a pyrazole compound that potently and selectively antagonizes TRPC3. Pyr3 inhibits TRPC3 by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.

Members of the canonical transient receptor potential (TRPC) channel family are ion channels which conduct Ca+2 and are activated by membrane receptor-mediated stimulation of phospholipase C (PLC) activity. However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). BTP1 and BTP2 are pyrazoles that block TRPC channels, but they are not specific for TRPC subtypes. This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca+2 oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.

Code de la classe de stockage

11 - Combustible Solids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 3

1 of 3

T16Ainh-A01 ≥95% (HPLC)

Sigma-Aldrich

SML0493

T16Ainh-A01

Nifedipine ≥98% (HPLC), powder

Sigma-Aldrich

N7634

Nifedipine

Thapsigargine ≥98% (HPLC), solid film

Sigma-Aldrich

T9033

Thapsigargine

Maria Cristina D Picardo et al.
PLoS biology, 17(2), e2006094-e2006094 (2019-02-23)
Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca2+)-activated nonselective cationic current (ICAN) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing ICAN is predicted to slow down or stop breathing; its contributions to motor
Yi-Fan Wu et al.
Cell & bioscience, 7, 28-28 (2017-05-27)
Chloroquine, a bitter tastant, inhibits Ca In this study, thapsigargin (TG), but not caffeine, induced sustained intracellular Ca These results indicate that chloroquine inhibits Ca
Cheng Cai et al.
Archives of toxicology, 93(4), 1009-1020 (2019-02-27)
Particulate matter (PM) is one of the most important environmental issues worldwide, which is associated with not only pulmonary but also cardiovascular diseases. However, the underlying biological mechanisms of PM related cardiovascular dysfunction remained poorly defined, especially mediated by the
Naoya Hirata et al.
International journal of molecular sciences, 23(4) (2022-02-27)
Triple-negative breast cancer (TNBC) is a highly aggressive cancer for which targeted therapeutic agents are limited. Growing evidence suggests that TNBC originates from breast cancer stem cells (BCSCs), and elucidation of the molecular mechanisms controlling BCSC proliferation will be crucial
Wenya Du et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 30(4), 1754-1774 (2022-01-26)
Acute pancreatitis (AP) is a common digestive disease without specific treatment, and its pathogenesis features multiple deleterious amplification loops dependent on translation, triggered by cytosolic Ca2+ ([Ca2+]i) overload; however, the underlying mechanisms in Ca2+ overload of AP remains incompletely understood.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique