O2136

Oleamide

≥99% (TLC), powder, sleep-inducing brain lipid

• Synonyme(s) : cis-9,10-Octadecenoamide, cis-9-Octadecenamide, Oleic acid amide
• Formule empirique (notation de Hill): C₁₈H₃₅NO
• Numéro CAS: 301-02-0
• Poids moléculaire : 281.48
• Numéro CE : 206-103-9
• Numéro MDL: MFCD00053638
• Code UNSPSC : 12352200
• ID de substance PubChem : 24897957
• Nomenclature NACRES : NA.77

Propriétés

• product name: Oleamide, ≥99%
• Niveau de qualité: 200
• Pureté: ≥99%
• Contrôle du médicament: regulated under CDSA - not available from Sigma-Aldrich Canada
• Température de stockage: −20°C
• Chaîne SMILES: CCCCCCCC\C=C/CCCCCCCC(N)=O
• InChI: 1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9-
• Clé InChI: FATBGEAMYMYZAF-KTKRTIGZSA-N

Description

Description générale

Oleamide is a lipid or a brain fatty acid, that is found in the CSF (cerebrospinal fluid). It is originally obtained from the cerebrospinal fluid of cats, that are sleep-deprived.

Application

Oleamide has been used as a supplement in glucose and galactose media to prevent the rescue of galactose-induced Leigh syndrome (LS).

Actions biochimiques/physiologiques

Oleamide has the ability to stimulate sleep. It possess several properties, like cannabinoid-like activity. Oleamide can also disable the communication, facilitated by gap junction between rat glial cells.

Sleep-inducing brain lipid, which allosterically modulates GABA_A receptors and potentiates 5-HT₇ serotonin receptor responses. Selective endogenous agonist of rat and human CB1 cannabinoid receptor.

Informations sur la sécurité

• Mentions de danger: H413
• Conseils de prudence: P273 - P501
• Classification des risques: Aquatic Chronic 4
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 404.6 °F - closed cup
• Point d'éclair (°C): 207 °C - closed cup
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves