N7537

NSC 663284

≥98% (HPLC), solid

• Synonyme(s) : 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
• Formule empirique (notation de Hill): C₁₅H₁₆ClN₃O₃
• Numéro CAS: 383907-43-5
• Poids moléculaire : 321.76
• Numéro MDL: MFCD08276924
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724556
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: protect from light
• Couleur: red
• Solubilité: DMSO: ≥10 mg/mL; H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
• InChI: 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
• Clé InChI: BMKPVDQDJQWBPD-UHFFFAOYSA-N
• Informations sur le gène: human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)

Description

Application

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Actions biochimiques/physiologiques

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 470.1 °F
• Point d'éclair (°C): 243.4 °C
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves