N5501

N_ω-Nitro-L-arginine

≥98% (TLC)

• Synonyme(s) : L-NNA, N⁵-(Nitroamidino)-L-2,5-diaminopentanoic acid, N^G-NO₂-L-Arg
• Formule empirique (notation de Hill): C₆H₁₃N₅O₄
• Numéro CAS: 2149-70-4
• Poids moléculaire : 219.20
• Numéro Beilstein : 1728914
• Numéro CE : 218-418-9
• Numéro MDL: MFCD00007033
• Code UNSPSC : 12352209
• ID de substance PubChem : 24278010
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Pureté: ≥98% (TLC)
• Forme: powder
• Pf: 257 °C
• Solubilité: 1 M HCl: 50 mg/mL, clear, colorless to faintly yellow
• Chaîne SMILES: N[C@@H](CCCNC(=N)N[N+]([O-])=O)C(O)=O
• InChI: 1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1
• Clé InChI: MRAUNPAHJZDYCK-BYPYZUCNSA-N
• Informations sur le gène: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) ; mouse ... Nos2(18126) ; rat ... Grin2a(24409) , Nos1(24598)

Description

Application

N_ω-Nitro-L-arginine has been used:

• as nitric oxide synthase (NOS) inhibitor, to measure the release of nitric oxide (NO) derivatives in cytochrome c reduction assay
• to pretreat fiber bundles for contractile studies
• as NOS inhibitor to characterize the generation of NO in Taxus yunnanensis cells
• as an irreversible inhibitor of the neuronal NO synthase (nNOS) to preincubate swimbladder preparations

Actions biochimiques/physiologiques

N_ω-Nitro-L-arginine/L-NNA helps to reduce the levels of cortical hyperemia and brain cGMP occurring due to hypercapnia.

Irreversible inhibitor of constitutive nitric oxide synthase (nNOS) and a reversible inhibitor of inducible nitric oxide synthase (iNOS).

Caractéristiques et avantages

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)