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N170

Sigma-Aldrich

NS 1619

powder

Synonyme(s) :

1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

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About This Item

Formule empirique (notation de Hill):
C15H8F6N2O2
Numéro CAS:
153587-01-0
Poids moléculaire :
362.23
Numéro MDL:
MFCD00928190
Code UNSPSC :
12352200
ID de substance PubChem :
24277860
Nomenclature NACRES :
NA.32

Forme

powder

Couleur

white

Solubilité

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL
ethanol: 26.6 mg/mL
0.1 M NaOH: 5.2 mg/mL
DMSO: 5.3 mg/mL
H2O: insoluble

Chaîne SMILES 

Oc1ccc(cc1N2C(=O)Nc3cc(ccc23)C(F)(F)F)C(F)(F)F

InChI

1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)

Clé InChI

YLFMCMWKHSDUCT-UHFFFAOYSA-N

Informations sur le gène

mouse ... Kcnma1(16531)
rat ... Kcnma1(83731)

Application

NS 1619 has been used as calcium-activated potassium channels (BK)-activator: to study its vaso-relaxing effects on the thoracic aortic rings from mice, to evaluate its effects on the sarco-/endoplasmic reticulum Ca2+-ATPase (SERCA) activity from skeletal muscles, to determine its effects on the expression of caveolin-1 protein in mice brain tumor microvascular endothelial cells

Actions biochimiques/physiologiques

NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.
NS-1619 can promote the formation of mitochondrial reactive oxygen species (ROS) in cardiac myocytes. It enhances the formation of ROS in cultured brain slices. NS-1619 has the ability to enhance HO-1 activity in wild-type (WT) animals.

Attention

Photosensitive

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Rui-Ping Cai et al.
Journal of the neurological sciences, 369, 109-118 (2016-09-23)
NS1619, a calcium-activated potassium channel (Kca channel) activator, can selectively and time-dependently accelerate the formation of transport vesicles in both the brain tumor capillary endothelium and tumor cells within 15min of treatment and then increase the permeability of the blood-brain
Antoni Wrzosek
Cell calcium, 56(1), 14-24 (2014-05-13)
NS1619 (1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazole-2-one) is widely used as a large-conductance Ca(2+)-activated K(+) (BKCa) channel opener. It was previously reported that activation of BKCa channels by NS1619 could protect the cardiac muscle against ischaemia and reperfusion injury. This study reports the effects of
Rupal P Soder et al.
European journal of pharmacology, 670(1), 252-259 (2011-09-15)
Large conductance voltage- and Ca(2+)-activated K(+) (BK) channels are important in regulating detrusor smooth muscle (DSM) function. Here, we examined systematically how the BK channel pharmacological activation modulates DSM contractility. NS1619, a potent BK channel activator, was utilized as a
Yajun Liu et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(1), G44-G54 (2011-09-17)
The objectives of this study were to determine whether neutrophil depletion with anti-neutrophil serum (ANS) or preconditioning with the hydrogen sulfide (H(2)S) donor NaHS (NaHS-PC) 24 h prior to ischemia-reperfusion (I/R) would prevent postischemic mitochondrial dysfunction in rat intestinal mucosa
Vincenzo Calderone et al.
Naunyn-Schmiedeberg's archives of pharmacology, 375(1), 73-80 (2007-01-05)
Large-conductance calcium-activated potassium channels (BK) of smooth muscle play a role in the relevant modulation of vascular tone, due to their calcium- and voltage-dependent mechanisms of activation. A potential role of endothelial BK channels has also been suggested by approaches
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