MAK378
Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit
100 fluorometric tests
Synonyme(s) :
ACE2 Inhibitor Discovery Kit
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About This Item
Code UNSPSC :
12161503
Nomenclature NACRES :
NA.84
Produits recommandés
Utilisation
100 fluorometric tests
Application(s)
pharmaceutical
Méthode de détection
fluorometric
Maladie(s) pertinente(s)
immunological diseases; cardiovascular diseases; genitourinary disorders; pulmonary disorders
Température de stockage
−20°C
Description générale
Angiotensin II converting enzyme (ACE2), a carboxypeptidase, is part of the renin-angiotensin system (RAS) that controls regulation of blood pressure by cleaving the C-terminal dipeptide of Angiotensin II to convert it into Angiotensin 1-7. It also cleaves Angiotensin I to produce Ang 1-9, of unknown function. ACE2 is a receptor of human coronaviruses, such as SARS and HCoV-NL63. It is expressed on the vascular endothelial cells of heart and kidney. The inhibitors of ACE2 could be able to regulate hypertension by changing vascular permeability. Screening for small molecule and peptide inhibitors might also help in finding treatment for coronavirus mediated infection.
Caractéristiques et avantages
The Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit is compatible with high-throughput handling systems.
Adéquation
The kit is suitable for Screening/characterizing inhibitors/ligands of ACE2.
Principe
The Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit can be used to screen for potent inhibitors of ACE2 activity, it utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. In the presence of an ACE2 specific inhibitor, the enzyme loses its peptidase activity which results in decrease of fluorescence intensity.
Autres remarques
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
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