M1787

Manganese(II) chloride solution

BioReagent, for molecular biology, storage temp.:room temp

• Synonyme(s) : Manganese chlroide, Manganese(II) chloride, MnCl₂
• Formule linéaire : MnCl₂
• Numéro CAS: 7773-01-5
• Poids moléculaire : 125.84
• Numéro MDL: MFCD00011114
• Code UNSPSC : 12352302
• ID de substance PubChem : 24896693
• Nomenclature NACRES : NA.52

Propriétés

• Qualité: for molecular biology
• Niveau de qualité: 200
• Stérilité: 0.2 μm filtered
• Gamme de produits: BioReagent
• Forme: liquid
• Concentration: 1.00 M±0.01 M
• Traces de cations: heavy metals (as Pb): ≤5 ppm
• Activité étrangère: DNase, Exonuclease; NICKase, Endonuclease; and protease, none detected
• Température de stockage: room temp
• Chaîne SMILES: Cl[Mn]Cl
• InChI: 1S/2ClH.Mn/h2*1H;/q;;+2/p-2
• Clé InChI: GLFNIEUTAYBVOC-UHFFFAOYSA-L

Description

Description générale

Manganese (II) chloride (MnCl₂) might play a key role in integrin activation. Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson′s like symptoms called as manganism. MnCl₂ has been used in reverse transcription reaction mix to enhance the template-switching efficiency.

MnCl₂ solution is a source of manganese ions and has a variety of biological uses. In biochemistry, it can be used as a cofactor in restriction enzymes, such as BamH and EcoR V. In molecular biology, Mn₂⁺ can be substituted for Mg₂⁺ as a divalent metal ion to facilitate DNase I activity in presence of Ca₂⁺.

Application

Manganese (II) chloride solution has been used:

• in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease and manganese toxicity
• in high ionic strength reaction mixture to determine RNA polymerase I and II activity
• in reverse transcription reaction mix as a source of Mn₂⁺ ions

Informations sur la sécurité

• Pictogrammes: GHS08,GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H318,H373
• Conseils de prudence: P260 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Classification des risques: Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2
• Organes cibles: Brain
• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)