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M003

Sigma-Aldrich

R-(−)-Deprenyl hydrochloride

powder, ≥98% (HPLC)

Synonyme(s) :

(R)-(−)-N,α-Dimethyl-N-(2-propynyl)phenethylamine hydrochloride, R(−)-N-α-Dimethyl-N-2-propynyl-benzeneethanamine hydrochloride, Selegiline hydrochloride

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About This Item

Formule empirique (notation de Hill):
C13H17N · HCl
Numéro CAS:
14611-52-0
Poids moléculaire :
223.74
Numéro MDL:
MFCD00069299
Code UNSPSC :
12352200
ID de substance PubChem :
24278577
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Activité optique

[α]25/D −10.8°, c = 6.48 in H2O(lit.)

Couleur

white

Pf

141-142  °C

Solubilité

H2O: >10 mg/mL

Auteur

Sanofi Aventis

Chaîne SMILES 

Cl[H].C[C@H](Cc1ccccc1)N(C)CC#C

InChI

1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1

Clé InChI

IYETZZCWLLUHIJ-UTONKHPSSA-N

Informations sur le gène

human ... MAOB(4129)

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Actions biochimiques/physiologiques

Selective MAO-B inhibitor; anti-Parkinsonian agent.

Caractéristiques et avantages

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H336

Conseils de prudence

P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Michael M Monaghan et al.
Neuro-degenerative diseases, 7(1-3), 153-159 (2010-03-04)
Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by an increasing loss of dopaminergic neurons resulting in motor dysfunction. However, cognitive impairments in PD patients are a common clinical feature that has gained increased attention. The purpose of the
Dominic Lomiwes et al.
Journal of agricultural and food chemistry, 72(30), 16777-16789 (2024-07-19)
Previous clinical studies indicate that monoamine oxidase-B (MAO-B) inhibition by blackcurrants must be predominantly attributed to bioactives other than anthocyanins. In this natural products discovery study, MAO-A/B inhibitory phytochemicals were isolated from blackcurrants, and a double-blind crossover study investigated the
Olivia J Kalimon et al.
Experimental neurology, 363, 114356-114356 (2023-02-26)
Monoamine oxidase (MAO) is an enzyme located on the outer mitochondrial membrane that metabolizes amine substrates like serotonin, norepinephrine and dopamine. MAO inhibitors (MAOIs) are frequently utilized to treat disorders such as major depression or Parkinson's disease (PD), though their
Hojae Lee et al.
Nature neuroscience, 24(12), 1673-1685 (2021-11-17)
Amyotrophic lateral sclerosis (ALS) is a devastating disorder in which motor neurons degenerate, the causes of which remain unclear. In particular, the basis for selective vulnerability of spinal motor neurons (sMNs) and resistance of ocular motor neurons to degeneration in
J W Tetrud et al.
Science (New York, N.Y.), 245(4917), 519-522 (1989-08-04)
The effects of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that produces the symptoms of Parkinson's disease, can be fully prevented in experimental animals by inhibiting monoamine oxidase B. On the basis of this observation, a double-blind, placebo-controlled study in patients with early
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