L9787

L-655,708

≥98% (HPLC), powder

• Synonyme(s) : Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate, L-655708
• Formule empirique (notation de Hill): C₁₈H₁₉N₃O₄
• Numéro CAS: 130477-52-0
• Poids moléculaire : 341.36
• Numéro MDL: MFCD02684528
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278527
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Solubilité: DMSO: ≥6.0 mg/mL (Warmed); H₂O: insoluble
• Auteur: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Chaîne SMILES: CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12
• InChI: 1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
• Clé InChI: YKYOQIXTECBVBB-AWEZNQCLSA-N
• Informations sur le gène: human ... GABRA5(2558)

Description

Application

L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.

Actions biochimiques/physiologiques

L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.

Novel ligand selective for the benzodiazepine site of GABA_A receptors which contain the α₅ subunit.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)