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Key Documents

I3661

Sigma-Aldrich

Insulin-FITC labeled human

recombinant, expressed in yeast, lyophilized powder

Synonyme(s) :

FITC Insulin, Labeled Human Insulin

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About This Item

Numéro CE :
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.83

Produit recombinant

expressed in yeast

Niveau de qualité

Forme

lyophilized powder
solid

Composition

Insulin, ≥75% biuret

Ampleur du marquage

≥1 mol FITC per mol insulin

Conditions d'expédition

dry ice
dry ice

Température de stockage

−20°C
−20°C

Description générale

Insulin is a polypeptide hormone mainly secreted from pancreas when glucose level changes in the plasma. It is an anabolic hormone and enhances the generation of storage substances, for instance glycogen, fat and protein. It also induces glucose uptake by peripheral tissues, thereby controlling glucose levels in the plasma. Its main sites of action are liver, adipose tissue and muscle.

Application

Insulin-FITC labeled human has been used in primary endothelial cells from human adipose tissue microvasculature (HAMEC) to study insulin transcytosis.

Forme physique

Lyophilized powder containing sodium phosphate buffer salts

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Espinal J
Understanding Insulin Action: Principles and Molecular Mechanisms (1989)
Cristina C Clement et al.
Scientific reports, 8(1), 11253-11253 (2018-07-28)
Transport of tissue-derived lymphatic fluid and clearance by draining lymph nodes are pivotal for maintenance of fluid homeostasis in the body and for immune-surveillance of the self- and non-self-proteomes. Yet a quantitative analysis of nodal filtration of the tissue-derived proteome
Mahmoud S Alghamri et al.
ACS nano, 16(6), 8729-8750 (2022-05-27)
Glioblastoma (GBM) is an aggressive primary brain cancer, with a 5 year survival of ∼5%. Challenges that hamper GBM therapeutic efficacy include (i) tumor heterogeneity, (ii) treatment resistance, (iii) immunosuppressive tumor microenvironment (TME), and (iv) the blood-brain barrier (BBB). The
Aaron L Glieberman et al.
Lab on a chip, 19(18), 2993-3010 (2019-08-30)
Pancreatic β cell function is compromised in diabetes and is typically assessed by measuring insulin secretion during glucose stimulation. Traditionally, measurement of glucose-stimulated insulin secretion involves manual liquid handling, heterogeneous stimulus delivery, and enzyme-linked immunosorbent assays that require large numbers
Hanwoong Woo et al.
Molecular brain, 11(1), 37-37 (2018-07-05)
Chronic stress is a psychologically significant factor that impairs learning and memory in the hippocampus. Insulin signaling is important for the development and cognitive function of the hippocampus. However, the relation between chronic stress and insulin signaling at the molecular

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