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Key Documents

H7509

Sigma-Aldrich

(Hydroxypropyl)methyl cellulose

viscosity 2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)

Synonyme(s) :

2-Hydroxypropyl methyl cellulose ether

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About This Item

Numéro CAS:
Numéro MDL:
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.25

Source biologique

plant

Niveau de qualité

Forme

powder

Poids mol.

~86 kDa

Couleur

white to off-white

Viscosité

2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)

Solubilité

water: 10 mg/mL, clear to very slightly hazy, colorless

Température de stockage

room temp

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Description générale

(Hydroxypropyl)methylcellulose (HPMC) is a water-soluble polymer derived from cellulose. This polysaccharide forms colloids when dissolved in water. HPMC is a hydrocolloid produced artificially from natural substances. It consists of 28-30% methoxyl content and 7-12% of hydroxypropoxyl content.

Application

(Hydroxypropyl)methyl cellulose (HPMC) has been used:
  • as a viscosity modifier in the preparation of printable ink
  • as a viscosifier in the preparation of hydroxyapatite (HAP) suspension
  • in the preparation of HPMC gels and composite gels

Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

Actions biochimiques/physiologiques

(Hydroxypropyl)methylcelluloses (HPMCs) act as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers. Additionally, solutions of these polymers show thermal gelation properties. They are generally used as binders, thickeners, film formers, and water retention agents. HPMC also elicits surface-active properties.

Caractéristiques et avantages

Dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface active and enzyme resistant. Solutions are pseudoplastic.

Autres remarques

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Alexandre Goyon et al.
Electrophoresis, 39(16), 2083-2090 (2018-05-19)
The determination of mAb critical quality attributes (CQA) is crucial for their successful application in health diseases. A generic CZE method was developed for the high-resolution separation of various mAb charge variants, which are often recognized as important CQA. A
Jenny Högström et al.
Cancer research, 78(20), 5820-5832 (2018-08-30)
The homeobox transcription factor PROX1 is induced by high Wnt/β-catenin activity in intestinal adenomas and colorectal cancer, where it promotes tumor progression. Here we report that in LGR5+ colorectal cancer cells, PROX1 suppresses the Notch pathway, which is essential for
Bernd Moritz et al.
Electrophoresis, 38(24), 3136-3146 (2017-09-10)
CZE is a well-established technique for charge heterogeneity testing of biopharmaceuticals. It is based on the differences between the ratios of net charge and hydrodynamic radius. In an extensive intercompany study, it was recently shown that CZE is very robust
Michelle Lay Teng Ang et al.
Infection and immunity, 82(5), 1850-1859 (2014-02-26)
Tuberculosis remains a major worldwide epidemic because of its sole etiological agent, Mycobacterium tuberculosis. Ethionamide (ETH) is one of the major antitubercular drugs used to treat infections with multidrug-resistant M. tuberculosis strains. ETH is a prodrug that requires activation within
Mylène Tajan et al.
Nature communications, 12(1), 366-366 (2021-01-16)
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice. However, numerous mechanisms promote resistance to this therapeutic approach, including enhanced expression of the de

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