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Merck
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Key Documents

H6036

Sigma-Aldrich

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole

powder, ≥98% (HPLC)

Synonyme(s) :

PPT

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About This Item

Formule empirique (notation de Hill):
C24H22N2O3
Numéro CAS:
263717-53-9
Poids moléculaire :
386.44
Numéro MDL:
MFCD03453628
Code UNSPSC :
51111800
ID de substance PubChem :
24278470
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to tan

Solubilité

DMSO: soluble 20 mg/mL
H2O: insoluble

Température de stockage

2-8°C

Chaîne SMILES 

CCCc1c(nn(-c2ccc(O)cc2)c1-c3ccc(O)cc3)-c4ccc(O)cc4

InChI

1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3

Clé InChI

IOTXSIGGFRQYKW-UHFFFAOYSA-N

Informations sur le gène

human ... ESR1(2099)

Description générale

Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.

Application

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole has been used to cultivate differentiated adipocytes. It is also used in drug treatments and radioimmunoassay (RIA).

Actions biochimiques/physiologiques

Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.
PPT is a specific estrogen receptor α (ERα) agonist.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Pituitary estrogen receptor alpha is involved in luteinizing hormone pulsatility at mid-gestation in the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha)
Proietto S, et al.
General and Comparative Endocrinology, 433(12), 35-46 (2018)
Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression
Avila R M, et al.
Molecular and Cellular Endocrinology, 433(12), 35-46 (2016)
Naohito Kitamura et al.
PloS one, 4(4), e5159-e5159 (2009-04-10)
The M(5) muscarinic acetylcholine receptor is known to play a crucial role in mediating acetylcholine dependent dilation of cerebral blood vessels. Previously, we reported that male M(5) muscarinic acetylcholine knockout mice (M5R(-/-) mice) suffer from a constitutive constriction of cerebral
Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus
Waters E M, et al.
Brain Research, 1290(11), 1-11 (2009)
Maryam Iravani et al.
The Journal of endocrinology, 232(3), 403-410 (2016-12-22)
Estrogens are well known for their capacity to promote bone maturation and at high doses to induce growth plate closure and thereby stop further growth. High-dose estrogen treatment has therefore been used to limit growth in extremely tall girls. However
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