H4628

DL-Homocysteine

≥95% (titration)

• Synonyme(s) : 2-Amino-4-mercaptobutyric acid
• Formule linéaire : HSCH₂CH₂CH(NH₂)COOH
• Numéro CAS: 454-29-5
• Poids moléculaire : 135.18
• Beilstein: 1721683
• Numéro CE : 207-222-9
• Numéro MDL: MFCD00004898
• Code UNSPSC : 12352209
• eCl@ss : 42021308
• ID de substance PubChem : 24895646
• Nomenclature NACRES : NA.26

Propriétés

• Nom du produit: DL-Homocysteine, ≥95% (titration)
• Niveau de qualité: 200
• Essai: ≥95% (titration)
• Forme: powder
• Pf: 232-233 °C (lit.)
• Solubilité: H₂O: soluble
• Application(s): cell analysis; peptide synthesis
• Température de stockage: −20°C
• Chaîne SMILES: NC(CCS)C(O)=O
• InChI: 1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)
• Clé InChI: FFFHZYDWPBMWHY-UHFFFAOYSA-N

Description

Application

DL-Homocysteine has been used to induce hyperhomocysteinemia in Sprague–Dawley rats. It has also been used to study the effects of hyperhomocysteinemia on atherosclerosis in apolipoprotein E-deficient mice.[1][2]

Actions biochimiques/physiologiques

Homocysteine is a sulfhydryl-containing amino acid, synthesized from methionine. It is a non-essential, non-proteinogenic amino acid.[3] It is an important determinant of the methylation cycle and is present in the plasma in four forms. An abnormally high level of homocysteine leads to hyperhomocysteinemia and also promotes atherosclerosis.[4][5]

Increased plasma homocysteine is a risk factor for coronary heart disease and carcinogenesis; may be a marker for tumor cell growth.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)