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H4535

Sigma-Aldrich

Anti-Heme Oxygenase-1 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

Anti-HO-1, Anti-HSP32

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About This Item

Numéro MDL:
MFCD01092544
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~32 kDa

Espèces réactives

rat, mouse

Technique(s)

immunohistochemistry: 5 μg/mL
immunoprecipitation (IP): 10-20 μg/mL
western blot: 0.5-2 μg/mL

Numéro d'accès UniProt

P06762

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HMOX1(3162)
mouse ... Hmox1(15368)
rat ... Hmox1(24451)

Immunogène

Synthetic peptide surrounding amino acids near the N-terminus of human HO-1.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Western Blotting (1 paper)

Forme physique

Solution in phosphate buffered saline containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Lorenzo L F Glorie et al.
American journal of physiology. Renal physiology, 303(5), F681-F688 (2012-06-22)
Dipeptidyl peptidase 4 (DPP4) is an exopeptidase which modulates the function of its substrates, among which are insulin-releasing incretins. DPP4 inhibitors are currently used to improve glucose tolerance in type 2 diabetes patients. Inhibition of DPP4 exhibits protective effects on
Megan A Mahlke et al.
Pathobiology of aging & age related diseases, 1 (2011-01-01)
The anti-tumor effects of calorie restriction (CR) and the possible underlying mechanisms were investigated using ethylnitrosourea (ENU)-induced glioma in rats. ENU was given transplacentally at gestational day 15, and male offspring were used in this experiment. The brain from 4-
Abdulla K Salahudeen et al.
Transplantation, 91(2), 176-182 (2010-11-16)
Kidneys from brain-dead donors are cold preserved until transplanted. However, prolonged cold storage can contribute to allograft failure. Studies suggest that donor preconditioning with dopaminergics may reduce cold-ischemic transplant injury, but whether heme oxygenase (HO)-1 induction is an underlying mechanism
Alexander Leathem et al.
Antioxidants (Basel, Switzerland), 11(2) (2022-02-26)
The cyclic nitroxide TEMPOL exerts anti-oxidative and anti-inflammatory effects, and thus may provide therapeutic benefit in Parkinson's disease (PD), in which mitochondrial dysfunction, oxidative damage and inflammation have been implicated as pathophysiological mechanisms underlying the selective loss of dopaminergic neurons.
Lin Sun et al.
The Journal of biological chemistry, 291(11), 5688-5707 (2016-01-23)
Diabetic nephropathy (DN) is characterized by perturbations in metabolic/cellular signaling pathways with generation of reactive oxygen species (ROS). The ROS are regarded as a common denominator of various pathways, and they inflict injury on renal glomerular cells. Recent studies indicate
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