GW21075
Anti-CXCR4 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
Anti-C-X-C chemokine receptor type 4
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About This Item
Produits recommandés
Source biologique
chicken
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
rat, human, mouse
Fabricant/nom de marque
Genway 15-288-21075
Technique(s)
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... CXCR4(7852)
Immunogène
Immunogen Sequence: GI # 4503175, sequence 6-41
Recombinant chemokine (C-X-C motif) receptor 4 isoform b
Application
Anti-CXCR4 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Actions biochimiques/physiologiques
C-X-C chemokine receptor type 4 (CXCR-4) is a protein encoded by the CXCR4 gene in humans. It is expressed in various cell types and the mechanisms involved in the regulation of its expression are still unknown. CXCR4 is a cofactor for fusion and entry of T cell-tropic strains of HIV-1. It is a chemokine receptor that is overexpressed in certain cancer types and involved in migration toward distant organs. CXCR4 is associated with various functions such as embryo organogenesis, immunological functions and T lymphocyte trafficking. High CXCR4 expression can be helpful in predicting clear-cell renal cell carcinoma (ccRCC). It plays a vital role in modulating cell trafficking in hematopoietic stem cells and clonal B cells. CXCR4 plays an important role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. It is an efficient prognostic factor for breast cancer.
Forme physique
Solution in phosphate buffered saline containing 0.02% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Zhigang Zhang et al.
BMC cancer, 14, 49-49 (2014-01-31)
The chemokine receptor CXCR4 plays a significant role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. However, the clinical application of CXCR4 for breast cancer prognosis is still very limited. A meta-analysis
R Chase Cornelison et al.
Scientific reports, 8(1), 17057-17057 (2018-11-20)
Glioblastoma is the most common and malignant form of brain cancer. Its invasive nature limits treatment efficacy and promotes inevitable recurrence. Previous in vitro studies showed that interstitial fluid flow, a factor characteristically increased in cancer, increases glioma cell invasion
H An et al.
British journal of cancer, 110(9), 2261-2268 (2014-04-10)
Aberrant CXC chemokine receptor 4 (CXCR4) expressions in malignant tissues have been reported; however, its role in kidney cancer prognosis remains unknown. The aim of this study was to determine the prognostic value of CXCR4 expression in patients with clear-cell
A Caruz et al.
FEBS letters, 426(2), 271-278 (1998-05-23)
CXCR4 is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. Recently, CXCR4 has drawn unexpected attention as it was recently identified as a co-factor required for entry of
M Moriuchi et al.
Journal of immunology (Baltimore, Md. : 1950), 159(9), 4322-4329 (1997-10-31)
The chemokine receptor CXCR4 (also designated fusin and LESTR) is a cofactor for fusion and entry of T cell-tropic strains of HIV-1. CXCR4 is expressed in various cell types; however, the mechanisms involved in the regulation of its expression remain
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