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GW20087F

Sigma-Aldrich

Anti-Human Kappa Light Chain antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Immunoglobulin kappa

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About This Item

Numéro MDL:
MFCD00162517
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

chicken

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Fabricant/nom de marque

Genway 15-288-20087F

Technique(s)

western blot: suitable

Numéro d'accès UniProt

P01834

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... IGKC(3514)

Catégories apparentées

Immunogène

Human IgK (Kappa) native protein.

Application

Anti-Human Kappa Light Chain antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Immunoglobulin κ constant (IGKC) is a human gene that encodes the constant domain of κ-type light chains for antibodies. It is found on chromosome 2 in humans. IGKC acts as a strong prognostic marker in several human solid tumors, including breast cancer. Its expression may have a role for humoral immunity in breast cancer progression. IGKC is also found to be expressed in non-small lung cancer (NSCLC) and may act as a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response. Its has an independent protective impact on disease-free survival (DFS) and breast cancer-specific overall survival in node-negative breast cancer. IGKC acts as a novel diagnostic marker for risk stratification in human cancer and may help to exploit the humoral immune response for anticancer therapy.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Miriam Lohr et al.
Cancer letters, 333(2), 222-228 (2013-02-02)
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray.
Marcus Schmidt et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(9), 2695-2703 (2012-02-22)
Although the central role of the immune system for tumor prognosis is generally accepted, a single robust marker is not yet available. On the basis of receiver operating characteristic analyses, robust markers were identified from a 60-gene B cell-derived metagene
Zonglin Chen et al.
PloS one, 7(9), e44741-e44741 (2012-10-03)
Biomarkers of the immune system are currently not used as prognostic factors in breast cancer. We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients. IGKC expression was
Janardan P Pandey et al.
Immunobiology, 219(2), 113-117 (2013-09-24)
Immunoglobulin κ constant (IGKC) gene has recently been identified as a strong prognostic marker in several human solid tumors, including breast cancer. Although the mechanisms underlying the IGKC signature are not yet known, identification of tumor-infiltrating plasma cells as the

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