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G8634

Sigma-Aldrich

Guanosine 5′-[γ-thio]triphosphate tetralithium salt

≥90% (contains < 10% GDP, HPLC), powder

Synonyme(s) :

GTPγS tetralithium salt, GTP-γ-S-Li4, Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

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About This Item

Formule empirique (notation de Hill):
C10H12Li4N5O13P3S
Numéro CAS:
94825-44-2
Poids moléculaire :
562.98
Numéro Beilstein :
8182249
Numéro CE :
305-606-1
Numéro MDL:
MFCD00135151
Code UNSPSC :
41106305
ID de substance PubChem :
24895344
Nomenclature NACRES :
NA.77

Niveau de qualité

200

Pureté

≥90% (contains < 10% GDP, HPLC)

Forme

powder

Couleur

white to off-white

Solubilité

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

Clé InChI

AMQXJFWJOAWCPV-ZVQJTLEUSA-J

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Application

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:
  • as a component of lysis buffer
  • in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state
  • to couple with G- protein α, to study its effect on kinase activity

Actions biochimiques/physiologiques

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Sanchez BP, et al.
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Jing Geng et al.
Nature communications, 12(1), 3519-3519 (2021-06-12)
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR4 signal-mediated innate
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The Journal of biological chemistry, 299(1), 102764-102764 (2022-12-05)
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Bio-protocol, 11(8), e3995-e3995 (2021-06-15)
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