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G1001

Sigma-Aldrich

D-Glutamic acid

≥99% (TLC), suitable for ligand binding assays

Synonyme(s) :

(R)-2-Aminoglutaric acid, (R)-2-Aminopentanedioic acid, D-Glu, R-(−)-1-Aminopropane-1,3-dicarboxylic acid

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About This Item

Formule linéaire :
HO2CCH2CH2CH(NH2)CO2H
Numéro CAS:
6893-26-1
Poids moléculaire :
147.13
Numéro Beilstein :
1723800
Numéro CE :
230-000-8
Numéro MDL:
MFCD00063112
Code UNSPSC :
12352209
ID de substance PubChem :
24895031
Nomenclature NACRES :
NA.32

product name

D-Glutamic acid, ≥99% (TLC)

Niveau de qualité

200

Pureté

≥99% (TLC)

Forme

powder

Technique(s)

ligand binding assay: suitable

Couleur

white to off-white

Pf

200-202 °C (subl.) (lit.)

Chaîne SMILES 

N[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1

Clé InChI

WHUUTDBJXJRKMK-GSVOUGTGSA-N

Informations sur le gène

human ... CCR2(1231)

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Catégories apparentées

Description générale

D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.

Application

D-glutamic acid is suitable for use in the structure-affinity relationship (SAR)-study of GR (glutamate racemase) enzyme and its inhibitors.

Actions biochimiques/physiologiques

Unnatural isomer of glutamic acid.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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P Doublet et al.
Journal of bacteriology, 174(18), 5772-5779 (1992-09-01)
The murI gene of Escherichia coli, whose inactivation results in the inability to form colonies in the absence of D-glutamic acid, was identified in the 90-min region of the chromosome. The complementation of an auxotrophic E. coli B/r strain by
Matthew Volgraf et al.
Nature chemical biology, 2(1), 47-52 (2006-01-13)
The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory binding site is a mechanism of regulation found across protein classes, from enzymes to motors to signaling proteins. We
Katie L Whalen et al.
Molecular informatics, 30(5), 459-471 (2011-07-09)
Existing techniques which attempt to predict the affinity of protein-ligand interactions have demonstrated a direct relationship between computational cost and prediction accuracy. We present here the first application of a hybrid ensemble docking and steered molecular dynamics scheme (with a
Dimitri Ryczko et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(17), E2440-E2449 (2016-04-14)
Dopamine neurons are classically known to modulate locomotion indirectly through ascending projections to the basal ganglia that project down to brainstem locomotor networks. Their loss in Parkinson's disease is devastating. In lampreys, we recently showed that brainstem networks also receive
H Persson et al.
Molecular and cellular biology, 10(9), 4701-4711 (1990-09-01)
The gene encoding glutamic acid decarboxylase (GAD), the key enzyme in the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid, is shown to be expressed in the testis of several different species. Nucleotide sequence analysis of a cDNA clone isolated from
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Chromatograms

application for HPLC

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