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F3261

Sigma-Aldrich

[Glu1]-Fibrinopeptide B human

≥90% (HPLC)

Synonyme(s) :

Fibrinopeptide B

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About This Item

Formule empirique (notation de Hill):
C66H95N19O26
Numéro CAS:
103213-49-6
Poids moléculaire :
1570.57
Numéro MDL:
MFCD00076440
Code UNSPSC :
12352202
ID de substance PubChem :
329799697
Nomenclature NACRES :
NA.32

Source biologique

human

Niveau de qualité

200

Pureté

≥90% (HPLC)

Forme

powder

Technique(s)

LC/MS: suitable
electrophoresis: suitable

Numéro d'accès UniProt

P02675

Température de stockage

−20°C

Chaîne SMILES 

CC(C)[C@H](NC(=O)CNC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C66H95N19O26/c1-31(2)53(85-48(90)29-73-55(100)35(67)16-19-49(91)92)64(109)83-42(26-46(69)88)61(106)82-43(27-52(97)98)62(107)81-41(25-45(68)87)60(105)78-37(18-21-51(95)96)57(102)77-36(17-20-50(93)94)56(101)74-28-47(89)76-39(23-33-11-6-4-7-12-33)58(103)80-40(24-34-13-8-5-9-14-34)59(104)84-44(30-86)63(108)75-32(3)54(99)79-38(65(110)111)15-10-22-72-66(70)71/h4-9,11-14,31-32,35-44,53,86H,10,15-30,67H2,1-3H3,(H2,68,87)(H2,69,88)(H,73,100)(H,74,101)(H,75,108)(H,76,89)(H,77,102)(H,78,105)(H,79,99)(H,80,103)(H,81,107)(H,82,106)(H,83,109)(H,84,104)(H,85,90)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,110,111)(H4,70,71,72)/t32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,53-/m0/s1

Clé InChI

KPBJTGOVJLITON-OECXYHNASA-N

Informations sur le gène

human ... FGB(2244)

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Amino Acid Sequence

Glu-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg

Description générale

Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer. It is cleaved off from the N-terminal of the fibrinogen β chain. This peptide is composed of 14 amino acids.

Application

[Glu1]-Fibrinopeptide B human has been used:
  • during LC-MS to avoid cross-contamination and to analyze the performance of mass spectrometer and LC-instrument
  • for two-point calibration during 2D (dimensional) gel electrophoresis and protein identification by mass spectrometry of histidine (his)-Pup (prokaryotic ubiquitin-like protein) isolated from Mycobacterium smegmatis
  • for two-point calibration during one-dimensional gel electrophoresis and tandem mass spectrometry (MS) for the characterization of soluble protein sample obtained from the salivary gland homogenates of Cimex lectularius
  • as a standard for the correction of mass drift in data obtained from MS and MS/MS performed on peptides obtained from trypsin-digestion of protein disulfide isomerase (PDI)

Actions biochimiques/physiologiques

Fibrin formation is an essential part in wound healing and inflammation. Fibrinopeptide B (FPB) can also cause chemotactic migration of neutrophils, without the simultaneous release of lysosome enzymes. It is produced during the coagulation of fibrinogen, which is essential for physiological homeostasis. It is involved in various disorders such as thrombosis and disseminated intravascular coagulation.

Autres remarques

Lyophilized from 0.1% TFA in H2O

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Consulter la Bibliothèque de documents

Helena Firczuk et al.
The FEBS journal, 287(5), 925-940 (2019-09-15)
Control of complex intracellular pathways such as protein synthesis is critical to organism survival, but is poorly understood. Translation of a reading frame in eukaryotic mRNA is preceded by a scanning process in which a subset of translation factors helps
Gerold Schmitt-Ulms et al.
PloS one, 4(9), e7208-e7208 (2009-09-29)
In the more than twenty years since its discovery, both the phylogenetic origin and cellular function of the prion protein (PrP) have remained enigmatic. Insights into a possible function of PrP may be obtained through the characterization of its molecular
Delphine Vincent et al.
International journal of molecular sciences, 23(2) (2022-01-22)
Bread wheat is the most widely cultivated crop worldwide, used in the production of food products and a feed source for animals. Selection tools that can be applied early in the breeding cycle are needed to accelerate genetic gain for
Ivo M B Francischetti et al.
Journal of proteome research, 9(8), 3820-3831 (2010-05-06)
The evolution of insects to a blood diet leads to the development of a saliva that antagonizes their hosts' hemostasis and inflammation. Hemostasis and inflammation are redundant processes, and thus a complex salivary potion composed of dozens or near 100
Andrew T Crombie et al.
Nature, 510(7503), 148-151 (2014-04-30)
The climate-active gas methane is generated both by biological processes and by thermogenic decomposition of fossil organic material, which forms methane and short-chain alkanes, principally ethane, propane and butane. In addition to natural sources, environments are exposed to anthropogenic inputs
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