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E9505

Sigma-Aldrich

β-Estradiol 3-sulfate sodium salt

≥93%

Synonyme(s) :

1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate

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About This Item

Formule linéaire :
C18H23O5SNa
Numéro CAS:
4999-79-5
Poids moléculaire :
374.43
Numéro MDL:
MFCD00056553
Code UNSPSC :
51111800
ID de substance PubChem :
24894699
Nomenclature NACRES :
NA.77

Stérilité

non-sterile

Niveau de qualité

200

Pureté

≥93%

Forme

powder

Contient

~70% N-methyl-D-glucamine as stabilizer

Solubilité

methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

Conditions d'expédition

ambient

Température de stockage

room temp

Chaîne SMILES 

[Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1

Clé InChI

PYPVMTJYMKHIST-LBARCDFESA-N

Description générale

β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.

Application

β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.

Actions biochimiques/physiologiques

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.

Conditionnement

Package size based on steroid content

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Mentions de danger

H302 + H332,H351

Classification des risques

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

T M Saleh et al.
The American journal of physiology, 275(3 Pt 2), R770-R778 (1998-09-05)
Female mammals have an enhanced baroreflex sensitivity compared with their male counterparts, leading researchers to speculate that estrogen modulates autonomic tone. Therefore, this study tests the hypothesis that exogenous estrogen can enhance the baroreflex sensitivity of male rats. Male Sprague-Dawley
Charles E Wood
Endocrinology, 152(12), 4966-4973 (2011-09-29)
Estradiol (E(2)) is an important modifier of the activity of the fetal hypothalamus-pituitary-adrenal axis. We have reported that estradiol-3-sulfate (E(2)SO(4)) circulates in fetal blood in far higher concentrations than E(2) and that the fetal brain expresses steroid sulfatase, required for
Rebeca Martin-Skilton et al.
Aquatic toxicology (Amsterdam, Netherlands), 79(1), 24-30 (2006-06-30)
We have characterized hepatic phenol sulfotransferase (SULT) activities in two benthic fish species, Mullus barbatus and Lepidorhombus boscii, using p-nitrophenol, dopamine, 17beta-estradiol, 4-nonylphenol, and 1-naphthol as substrates. High affinity sulfation of 17beta-estradiol was observed in both species (Km=28-75 nM), suggesting
T Tanaka et al.
Journal of steroid biochemistry, 22(2), 285-288 (1985-02-01)
Antisera were prepared against two types of estradiol-3-sulfate-bovine serum albumin (BSA) conjugates. The haptens were coupled to BSA through the C-6 position in the steroid molecule by the glutaraldehyde (A) or the carbodiimide method (B). In comparison the antiserum produced
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, 122-122 (2015)
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