E6888

Enalapril maleate salt

powder, ≥98% (TLC)

• Synonyme(s) : (S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro maleate salt
• Formule empirique (notation de Hill): C₂₀H₂₈N₂O₅ · C₄H₄O₄
• Numéro CAS: 76095-16-4
• Poids moléculaire : 492.52
• Numéro CE : 278-375-7
• Code UNSPSC : 12352200
• ID de substance PubChem : 24894639
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (TLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: methanol: ≥50 mg/mL, clear, colorless to yellow
• Auteur: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Chaîne SMILES: C[C@@H](C(N1[C@H](C(O)=O)CCC1)=O)N[C@H](CC(OCC)=O)CCC2=CC=CC=C2.O=C(OO)/C=C\C(O)=O
• InChI: 1S/C21H30N2O5.C4H4O5/c1-3-28-19(24)14-17(12-11-16-8-5-4-6-9-16)22-15(2)20(25)23-13-7-10-18(23)21(26)27;5-3(6)1-2-4(7)9-8/h4-6,8-9,15,17-18,22H,3,7,10-14H2,1-2H3,(H,26,27);1-2,8H,(H,5,6)/b;2-1-/t15-,17-,18-;/m0./s1
• Clé InChI: UQKQUZOIQFOJOI-KJHLASMFSA-N

Description

Description générale

Enalapril is an angiotensin-converting enzyme inhibitor. It is used to treat heart failure and high blood pressure.

Application

Enalapril maleate salt has been used:

• to reduce albumin excretion rate (AER) and glomerular lesions
• to examine the effects of enalapril pre-treatment on myocardial injury
• to investigate its efficacious doses and schedules for mitigation of radiation lung injury

Actions biochimiques/physiologiques

A long-acting angiotensin-converting enzyme inhibitor.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H361fd
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)