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D7441

Sigma-Aldrich

Daltroban

>98% (HPLC)

Synonyme(s) :

4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148

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About This Item

Formule empirique (notation de Hill):
C16H16ClNO4S
Numéro CAS:
79094-20-5
Poids moléculaire :
353.82
Numéro MDL:
MFCD00868295
Code UNSPSC :
12352200
ID de substance PubChem :
24724468
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

>98% (HPLC)

Forme

solid

Couleur

white

Pf

132.5-137.4 °C (lit.)

Solubilité

DMSO: soluble 22 mg/mL

Chaîne SMILES 

OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1

InChI

1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)

Clé InChI

IULOBWFWYDMECP-UHFFFAOYSA-N

Informations sur le gène

human ... TBXA2R(6915)

Description générale

Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.

Actions biochimiques/physiologiques

Selective thromboxane A2 receptor antagonist

Caractéristiques et avantages

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Zhi-Dong Ge et al.
Journal of cardiovascular pharmacology, 41(3), 481-488 (2003-02-27)
The purpose of the current study was to compare the efficacy of two structurally unrelated thromboxane A (TXA ) receptor antagonists, KT2-962 and daltroban (BM 13.505), in a dog model of myocardial ischemia/reperfusion injury. Pentobarbital-anesthetized dogs were subjected to left
Sabine Pestel et al.
Laboratory investigation; a journal of technical methods and pathology, 83(12), 1733-1741 (2003-12-24)
Various inflammatory stimuli such as anaphylatoxin C5a, zymosan, and lipopolysaccharides (LPSs) have been reported both to enhance glucose output in the perfused rat liver and to induce prostanoid (ie, prostaglandin and thromboxane) release from Kupffer cells, the resident liver macrophages.
Milena Koleva et al.
Gastroenterology, 122(3), 697-708 (2002-03-05)
In normal rat liver, anaphylatoxin C5a induces glucose output from hepatocytes indirectly via prostanoids released from Kupffer cells. Correspondingly, it was found that hepatocytes, in contrast to Kupffer cells, did not express C5a receptors. Lipopolysaccharide (LPS) has been reported to
M Shimazawa et al.
European journal of pharmacology, 328(2-3), 183-189 (1997-06-11)
The antithrombotic effect of desethyl KBT-3022, which is the main active metabolite of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl] pyrrol-1-ylacetate; a cyclooxygenase inhibitor), was determined using a photochemically induced arterial thrombosis model in the rat femoral artery. Pretreatment with
A Rizzo et al.
The American journal of physiology, 268(5 Pt 2), H1954-H1958 (1995-05-01)
The effects of platelet-activating factor (PAF) on vascular resistance and capillary permeability were studied in the isolated rat hindquarter. Six groups were studied (n = 30): control; PAF alone (1.4 microM); and PAF (1.4 microM) pretreated with ibuprofen (30 mg/kg)
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