D4628

Diethylstilbestrol

≥99% (HPLC)

• Synonyme(s) : (E)-3,4-bis(4-hydroxyphényl)-3-hexène
• Formule empirique (notation de Hill): C₁₈H₂₀O₂
• Numéro CAS: 56-53-1
• Poids moléculaire : 268.35
• Numéro Beilstein : 2056095
• Numéro CE : 200-278-5
• Numéro MDL: MFCD00002373
• Code UNSPSC : 51111800
• ID de substance PubChem : 24893887
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Pureté: ≥99% (HPLC)
• Forme: powder
• Chaîne SMILES: CC\C(c1ccc(O)cc1)=C(\CC)c2ccc(O)cc2
• InChI: 1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+
• Clé InChI: RGLYKWWBQGJZGM-ISLYRVAYSA-N
• Informations sur le gène: human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Esr1(24890)

Description

Application

Diethylstilbestrol has been used:

• to evaluate the estrogenic activity of diethylstilbestrol by quantitating the expression levels of endogenous estrogen-regulated marker genes
• to evaluate the estrogenic, androgenic and toxicity responses in bioluminescent yeast bioreporter assay (BLYES)
• to detect its effect on the proliferation and tyrosinase activity of melanocytes

Actions biochimiques/physiologiques

Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H315,H319,H335,H350,H360FD,H410
• Conseils de prudence: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges